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PHA-20018 - Module Specification
School of Pharmacy and Bioengineering
Faculty of Medicine & Health Sciences

For academic year: 2023/24 Last Updated: 13 February 2024

PHA-20018 - Applied Pharmaceutical Science II
Coordinator: Pooya Davoodi Tel: +44 1782 7 33327
Lecture Time: See Timetable...
Level: Level 5
Credits: 30
Study Hours: 300
School Office:

Programme/Approved Electives for 2023/24

None

Available as a Free Standing Elective

No

Co-requisites

None

Prerequisites

None

Barred Combinations

None

Description for 2023/24

This module provides an integrated and fully contextualised analysis of crucial topics covering the breadth of the pharmaceutical sciences, especially the applied disciplines of pharmaceutics and pharmacology.
The linkages between core topics are highlighted at each Level of the programme and these Level 5 modules (for example, in this module, Applications of Pharmaceutical Science 1, and Applications of Pharmaceutical Science 2, and other modules) provide the fulcrum for the programme.
After a general introduction to pharmaceutics students will study the properties and applications of solutions, followed by rheology and the flow properties of liquids and semisolids. Interfacial phenomenon and disperse systems, including surface tension, surface active agents, emulsions, and suspensions will be covered in detail since these concepts are of vital importance in the performance of many dosage forms. Chemical kinetics, drug stability, and particle sizing will be introduced towards the end of the module, leading to an in-depth examination of product stability and quality assurance. All of the topics covered will be supported by a comprehensive programme of practical exercises. Alongside and integrated with the concepts in formulation science, the relevant aspects of the pharmacological actions of drugs on molecular targets, cells and physiological systems is covered systematically, including detailed coverage of the mechanisms by which drugs interact with physiological systems to exert therapeutic and adverse effects.
The potential and limitations of drug use will be expounded, including topics in combination therapy, adverse effects, resistance and abuse. Experimentation and data analysis is key to an understanding of pharmacology and an examination of the essential and appropriate techniques for the acquisition and analysis of experimental data will be provided. The application of a systematic understanding of drug-receptor interactions will be used to identify drugs and receptors from pharmacological data.
Woven throughout the module is development of essential team-working and leadership skills: group-based tasks within the laboratory classes and practical skills workshops provide students with a forum to demonstrate their potential to work in and lead interdisciplinary teams.

Aims
Building on PHA-20016, this module aims to provide an integrated and fully contextualised analysis of crucial topics covering the breadth of the pharmaceutical sciences, especially the applied disciplines of pharmaceutics and pharmacology.

Talis Aspire Reading List
Any reading lists will be provided by the start of the course.
http://lists.lib.keele.ac.uk/modules/pha-20018/lists

Intended Learning Outcomes

Demonstrate knowledge of and apply an integrated approach towards patient care which links pharmaceutical science and pharmaceutical manufacturing
: 1,2,3
Explain how patient physiology and pathophysiology affect the drug choice in the context of absorption, distribution, metabolism and excretion (ADME) models: 1,2,3
Explain the role of drug resistance and drug interactions in pharmaceutical development: 1,2,3
Explain the underpinning concepts in physical chemistry and materials science which underpin the formulation of parenteral, solid and semi-solid dosage forms: 1,2,3
Evaluate and select processes and formulations appropriate to the manufacture and testing of specified parenteral, solid and semi-solid dosage forms: 1,2,3
Describe the relevance of microbiology within the context of medicinal product quality: 1,2,3
Describe in detail the metabolic interrelationships of the various tissues and organs of the human body, including the role of hormones in the integration of metabolism and the maintenance of homeostasis
: 1,2,3
Demonstrate competence in pharmaceutical calculations related to pharmacology and pharmaceutics including a focus on parenteral, semi-solid, solid and particulate dose forms, with reference where appropriate to pharmacopoeial standards: 1,2,3
Recognise the role of the skin in percutaneous absorption, including dermal and transdermal delivery: 1,2,3

Study hours

Large- and small-group teaching sessions: 50 hours
Skills-based practical work: 50 hours
Directed private study, revision and assessment: 198 hours
Exam: 2 hours


School Rules

None

Description of Module Assessment

1: Laboratory Assessment weighted 25%
Laboratory skills assessment
The laboratory assessment will comprise elements from multiple laboratory sessions (3 x 3 hour sessions) and will focus on the pharmaceutics content of the module. The assessments will be: - the tablet manufacture and testing laboratory sessions This assessment involves students working in groups. There are two parts to the assessment: - the batch record sheet has to be completed by the group; this is a group assessment and students in the same group are awarded the same mark; this is weighted as 30% of the assessment - the laboratory report is assessed for each individual student; this is weighted as 70% of the assessment.

2: Practical Assessment weighted 25%
Practical skills assessment
The practical skills assessment will cover a variety of academic and professional skills-based tasks. This is comprised of a range of: - Biological Science: Leaflet preparation (word count: 750 words) - polymorphism essay (word count: 2000 words) These assessments will be carried out individually.

3: Exam weighted 50%
2 hour end of module exam
The end of module examination will contain a mix of multiple choice and short answer questions. Workshops and tutorials supporting the examinations are held throughout the academic year. The exam will contain online tests of Paper 1 (MCQ) (40%) and Paper 2 (LAQ)(40%). Low stake assessments (20% of this assessment component) will be incorporated within this component. Examples of low stake assessments may include MCQs, quizzes and other similar forms of assessment covering a variety of key topics from this module.

Please note that for the 2022/23 Academic Year programmes may be adapted to operate in accordance with a flexible, digital approach. This means that there may be some changes made to how modules are delivered and assessed. The latest information will be provided to you by your School in module handbooks. We endeavour to give you as much notice as possible of any changes and details about the circumstance in which changes are made to programmes can be found in the Student Agreement, available at: https://www.keele.ac.uk/student-terms-and-conditions/

Last Updated: 13 February 2024