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    Centre publications

    Selected publications

    Professor Gavin J. Miller

    • Hansen SU, Miller GJ, Cliff MJ, Jaysonc GC, Gardiner JM. 2015. Making the longest sugars: a chemical synthesis of heparin-related [4](n) oligosaccharides from 16-mer to 40-mer. CHEMICAL SCIENCE, 6158-6164, vol. 6(11). link> doi> link> full text>
    • Jayson GC, Hansen SU, Miller GJ, Cole CL, Rushton G, Avizienyte E, Gardiner JM. 2015. Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology. Chem Commun (Camb), 13846-13849, vol. 51(72). link> doi> full text>
    • Takemoto N, Suehara T, Frisco HL, Sato S-I, Sezaki T, Kusamori K, Kawazoe Y, Park SM, Yamazoe S, Mizuhata Y, Inoue R, Miller GJ, Hansen SU, Jayson GC, Gardiner JM, Kanaya T, Tokitoh N, Ueda K, Takakura Y, Kioka N, Nishikawa M, Uesugi M. 2013. Small-molecule-induced clustering of heparan sulfate promotes cell adhesion. J Am Chem Soc, 11032-11039, vol. 135(30). link> doi>
    • Hansen SU, Miller GJ, Cole C, Rushton G, Avizienyte E, Jayson GC, Gardiner JM. 2013. Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies. Nat Commun, 2016, vol. 4. link> doi>
    • Miller GJ, Hansen SU, Avizienyte E, Rushton G, Cole C, Jayson GC, Gardiner JM. 2013. Efficient chemical synthesis of heparin-like octa-, deca- and dodecasaccharides and inhibition of FGF2-and VEGF(165)-mediated endothelial cell functions. CHEMICAL SCIENCE, 3218-3222, vol. 4(8). link> doi> full text>

    Dr Mark Skidmore

    • Schuurs ZP, Hammond E, Elli S, Rudd TR, Mycroft-West CJ, Lima MA, Skidmore MA, Karlsson R, Chen Y-H, Bagdonaite I, Yang Z, Ahmed YA, Richard DJ, Turnbull J, Ferro V, Coombe DR, Gandhi NS. 2021. Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain. Comput Struct Biotechnol J, 2806-2818, vol. 19. link> doi> full text>
    • Mycroft-West CJ, Su D, Pagani I, Rudd TR, Elli S, Gandhi NS, Guimond SE, Miller GJ, Meneghetti MCZ, Nader HB, Li Y, Nunes QM, Procter P, Mancini N, Clementi M, Bisio A, Forsyth NR, Ferro V, Turnbull JE, Guerrini M, Fernig DG, Vicenzi E, Yates EA, Lima MA, Skidmore MA. 2020. Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. Thromb Haemost, 1700-1715, vol. 120(12). link> doi> full text>
    • Lima MA, Skidmore M, Khanim F, Richardson A. 2021. Development of a nano-luciferase based assay to measure the binding of SARS-CoV-2 spike receptor binding domain to ACE-2. Biochem Biophys Res Commun, 485-490, vol. 534. link> doi> full text>
    • Tree JA, Turnbull JE, Buttigieg KR, Elmore MJ, Coombes N, Hogwood J, Mycroft-West CJ, Lima MA, Skidmore MA, Karlsson R, Chen Y-H, Yang Z, Spalluto CM, Staples KJ, Yates EA, Gray E, Singh D, Wilkinson T, Page CP, Carroll MW. 2021. Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations. Br J Pharmacol, 626-635, vol. 178(3). link> doi> full text>
    • Mycroft-West CJ, Devlin AJ, Cooper LC, Guimond SE, Procter P, Guerrini M, Miller GJ, Fernig DG, Yates EA, Lima MA, Skidmore MA. 2021. Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer's Disease β Secretase, BACE1. Mar Drugs, vol. 19(4). link> doi> full text>

    Dr Marcelo Lima

    • Meneghetti MCZ, Ferreira TG, Tashima AK, Chavante SF, Yates EA, Liu J, Nader HB, Andrade De Lima M. 2017. Insights into the role of 3-O-sulfotransferase in heparan sulfate biosynthesis. Organic & biomolecular chemistry, 6792-6799, vol. 15(32). doi>
    • Hughes A, Meneghetti M, Huang T, Hung S, Elli S, Guerrini M, Rudd T, Lima M, Yates E. 2017. Investigating the relationship between temperature, conformation and calcium binding in heparin model oligosaccharides. Carbohydrate Research, 58-64, vol. 438. doi> link>
    • Stewart KL, Hughes E, Yates EA, Akien GR, Huang T, Lima MA, Rudd TR, Guerrini M, Hung S, Radford SE. 2016. Atomic details of the interactions of glycosaminoglycans with amyloid-β fibrils. Journal of the American Chemical Society, 8328-8331, vol. 138(27). doi> link> full text>
    • Meneghetti MCZ, Hughes AJ, Rudd TR, Nader HB, Powell AK, Yates EA, Lima MA. 2015. Heparan sulfate and heparin interactions with proteins. Journal of the Royal Society Interface, 20150589, vol. 12(110). doi> link>
    • Lima MA, Hughes AJ, Veraldi N, Rudd TR, Hussain R, Brito AS, Chavante SF, Tersariol II, Siligardi G, Nader HB. 2013. Antithrombin stabilisation by sulfated carbohydrates correlates with anticoagulant activity. MedChemComm, 870-873, vol. 4(5). doi> link> 

    Dr Scott Guimond

    • Davies SP, Mycroft-West CJ, Pagani I, Hill HJ, Chen Y-H, Karlsson R, Bagdonaite I, Guimond SE, Stamataki Z, De Lima MA, Turnbull JE, Yang Z, Vicenzi E, Skidmore MA, Khanim FL, Richardson A. 2021. The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models. Front Pharmacol, 660490, vol. 12. link> doi> full text>
    • Mycroft-West CJ, Su D, Pagani I, Rudd TR, Elli S, Gandhi NS, Guimond SE, Miller GJ, Meneghetti MCZ, Nader HB, Li Y, Nunes QM, Procter P, Mancini N, Clementi M, Bisio A, Forsyth NR, Ferro V, Turnbull JE, Guerrini M, Fernig DG, Vicenzi E, Yates EA, Lima MA, Skidmore MA. 2020. Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. Thromb Haemost, 1700-1715, vol. 120(12). link> doi> full text>
    • Ní Cheallaigh A, Guimond SE, Oscarson S, Miller GJ. 2020. Chemical synthesis of a sulfated d-glucosamine library and evaluation of cell proliferation capabilities. Carbohydr Res, 108085, vol. 495. link> doi> full text>
    • Miller RL, Guimond SE, Schwörer R, Zubkova OV, Tyler PC, Xu Y, Liu J, Chopra P, Boons G-J, Grabarics M, Manz C, Hofmann J, Karlsson NG, Turnbull JE, Struwe WB, Pagel K. 2020. Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides. Nature Communications, Article 1481, vol. 11(1). link> doi> link> full text>
    • Mycroft-West CJ, Devlin AJ, Cooper LC, Procter P, Miller GJ, Fernig DG, Guerrini M, Guimond SE, Lima MA, Yates EA, Skidmore MA. 2020. Inhibition of BACE1, the β-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus. Neural Regen Res, 1546-1553, vol. 15(8). link> doi> full text>

    Dr Johannes Reynisson

    • Wieczorek-Błauż A, Kowalczyk K, Błauż A, Makal A, Pawlędzio S, Eurtivong C, Arabshahi HJ, Reynisson J, Hartinger CG, Rychlik B, Plażuk D. 2021. Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates. Dalton Trans. link> doi>
    • Rees SWP, Leung E, Reynisson J, Barker D, Pilkington LI. 2021. Development of 2-Morpholino-N-hydroxybenzamides as anti-proliferative PC-PLC inhibitors. Bioorg Chem, 105152, vol. 114. link> doi>
    • Dyrkheeva NS, Filimonov AS, Luzina OA, Zakharenko AL, Ilina ES, Malakhova AA, Medvedev SP, Reynisson J, Volcho KP, Zakian SM, Salakhutdinov NF, Lavrik OI. 2021. New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition. Biomolecules, vol. 11(7). link> doi> full text>
    • Leung E, Patel J, Hollywood JA, Zafar A, Tomek P, Barker D, Pilkington LI, van Rensburg M, Langley RJ, Helsby NA, Squire CJ, Baguley BC, Denny WA, Reynisson J, Leung IKH. 2021. Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs. Oncology and Therapy. link> doi> full text>
    • Marijan S, Mastelić A, Markotić A, Režić-Mužinić N, Vučenović N, Barker D, Pilkington LI, Reynisson J, Čulić VČ. 2021. Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells. Medicines (Basel), vol. 8(7). link> doi> full text>

    Dr Sebastian Cosgrove

    • Mattey AP, Ford GJ, Citoler J, Baldwin C, Marshall JR, Palmer RB, Thompson M, Turner NJ, Cosgrove SC, Flitsch SL. 2021. Back Cover: Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades (Angew. Chem. Int. Ed. 34/2021). Angewandte Chemie International Edition, 18892, vol. 60(34). doi>
    • Mattey AP, Ford GJ, Citoler J, Baldwin C, Marshall JR, Palmer RB, Thompson M, Turner NJ, Cosgrove SC, Flitsch SL. 2021. Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades. Angewandte Chemie, Article ange.202107128. doi>
    • Mattey AP, Ford GJ, Citoler J, Baldwin C, Marshall JR, Palmer RB, Thompson M, Turner NJ, Cosgrove SC, Flitsch SL. 2021. Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades**. Angewandte Chemie, 2-8, vol. 133. doi> link> full text>
    • Mattey AP, Ford GJ, Citoler J, Baldwin C, Marshall JR, Palmer RB, Thompson M, Turner NJ, Cosgrove SC, Flitsch SL. 2021. Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades*. Angew Chem Int Ed Engl, 18660-18665, vol. 60(34). link> doi> full text>
    • Mattey AP, ford G, Citoler J, Baldwin C, Marshall J, Pamer R, thompson MP, Turner N, Cosgrove S, Flitsch S. 2021. Production of High Value Amine Intermediates via Biocatalytic Cascades in Continuous Flow. Organic Chemistry. doi> link> full text>