Thrombosis and Haemostasis research group
Our research group interest seeks to understand the molecular and cellular events that underlie human blood clotting, and how these become dysfunctional in acute cardiovascular disease.
Using vascular tissue engineering techniques, we recreate the conditions found inside the human body so that we can understand these signalling events under physiologically-relevant conditions.
These studies help provide new methods to develop and screen anti-thrombotic drugs to help improve outcomes in people experiencing heart attacks and strokes.
Research topic areas
- The use of artificial tissue engineered human arteries as a replacement for animal thrombosis models in the study of clotting responses to vascular injury, atherosclerotic plaque rupture and bleeds on the brain.
- Using clot-targeted magnetic nanoparticles to improve the efficacy of clot-busting drugs in stroke treatment.
- Assessing the role of the open canalicular system and membrane complex in controlling calcium signalling in human platelets.