People

Professor Nicholas Forsyth’s research group is based at the Keele University Hartshill campus and located in the Guy Hilton Research Centre. Nicholas joined the Keele University Institute of Science and Technology in Medicine in 2006 after having performed postdoctoral research at the Roslin Institute (Edinburgh, UK) and the University of Texas Southwestern Medical Centre (Dallas, USA). He became a Professor at Keele in 2015.

The research interests of the group lie in the development and application of advanced cell culture environments for the optimized expansion and differentiation of adult and embryonic stem cells. This includes control of multiple parameters such as oxygen tension, metabolite levels, substrate composition, and growth factor supplementation. The group has specific interests in the development/optimization of differentiation assays for turning stem cells into tendons and have made substantial progress in this area in recent times.

Relevant background publications in 2008-9: 
1) Wimpenny I, Hampson K, Yang Y, Ashammakhi N, Forsyth NR. One step recovery of marrow stromal cells on nanofibers. Tissue Eng Part C Methods. 2009 Aug 17. [Epub ahead of print] PubMed PMID: 19686057. 
2) Bullough R, Finnigan T, Kay A, Maffulli N, Forsyth NR. Tendon repair through stem cell intervention: cellular and molecular approaches. Disabil Rehabil.2008;30(20-22):1746-51. Review. PubMed PMID: 18720123. 
3) Forsyth NR, Kay A, Hampson K, Downing A, Talbot R, McWhir J. Transcriptome alterations due to physiological normoxic (2% O2) culture of human embryonic stem cells. Regen Med. 2008 Nov;3(6):817-33. PubMed PMID: 18947306.