Dr Mark Skidmore
- Title
- Senior Lecturer
- Location
- Huxley Building : 174
- Contact me
- Try my office or e-mail to set up an appointment.
- Phone
- +44 (0)1782 733945
- m.a.skidmore@keele.ac.uk
Biography
Biography
Dr Mark Skidmore was appointed as Lecturer in Biochemistry at Keele in October 2010, having spent 4 years as Research Associate at Liverpool University, where he had previously completed his PhD in 2006 on “Heparin / heparan sulphate method development and protein interactions” under the supervision of Prof JE Turnbull and Dr EA Yates.
His first degree and diploma in Biochemistry were at Imperial College London, and he has built up a range of links across academic collaborations and industrial partnerships.
Research and scholarship
Research and scholarship
The general area of Dr Skidmore’s research interests is carbohydrate chemistry/biochemistry, in particular the role of anionic carbohydrates (for example the glysoaminoglycans (GAGs) as dynamic cell regulators.
The major focus of his current research is the study of carbohydrate:protein structure-functions, in particular the development of new tools and technologies for elucidating protein-carbohydrate interactions and their application to biomedical sciences, biological sciences and medicine.
Publications
Publications
Journal Articles
- Dolan, Jonathan P.; Ahmadipour, Sanaz; Wahart, Alice J. C.; Cheallaigh, Aisling Ní; Sari, Suat; Eurtivong, Chatchakorn; Lima, Marcelo A.; Skidmore, Mark A.; Volcho, Konstantin P.; Reynisson, Jóhannes; Field, Robert A.; Miller, Gavin J.. . 'Correction: Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors'. RSC Chemical Biology. DOI > view in repository >
- Mycroft-West, Courtney J.; Abdelkarim, Sahar; Duyvesteyn, Helen M. E.; Gandhi, Neha S.; Skidmore, Mark A.; Owens, Raymond J.; Wu, Liang. . 'Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1'. Nature Communications. DOI > view in repository >
- Wahart, Alice J. C.; Dolan, Jonathan P.; Anderson, Simon D.; Cheallaigh, Aisling Ní; Staniland, Jessica; Lima, Marcelo A.; Skidmore, Mark A.; Miller, Gavin J.; Cosgrove, Sebastian C.. 09-11-2023. 'Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides'. ChemBioChem. DOI > view in repository >
- Wahart, Alice J C; Dolan, Jonathan P; Anderson, Simon D; Cheallaigh, Aisling Ní; Staniland, Jessica; Lima, Marcelo A; Skidmore, Mark A; Miller, Gavin J; Cosgrove, Sebastian C. . 'Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides.'. Chembiochem : a European journal of chemical biology. DOI > view in repository >
- Dolan, Jonathan; Ahmadipour, Sanaz; Wahart, Alice; Ni Cheallaigh, Aisling; Sari, Suat; Eurtivong,, Chatchakorn; Lima, Marcelo; Skidmore, Mark; Volcho, Konstantin; Reynisson, Jóhannes; Field, Robert; Miller, Gavin. 29-08-2023. 'Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors †'. RSC Chemical Biology. DOI > view in repository >
- Andrade De Lima, M; Skidmore, M; Khanim, F; Richardson, A. 11-11-2020. 'Development of a nano-luciferase based assay to measure the binding of SARS-CoV-2 spike receptor binding domain to ACE-2'. Biochemical and Biophysical Research Communications. DOI > view in repository >
- Mycroft-West, Courtney; Su, Dunhao; Elli, Stefano; Li, Yong; Guimond, Scott; Miller, Gavin; Turnbull, Jeremy; Yates, Edwin; Guerrini, Marco; Fernig, David; Lima, Marcelo; Skidmore, Mark. 01-01-2020. 'The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding'. . DOI > view in repository >
- Mycroft-West, Courtney J.; Su, Dunhao; Li, Yong; Guimond, Scott E.; Rudd, Timothy R.; Elli, Stefano; Miller, Gavin; Nunes, Quentin M.; Procter, Patricia; Bisio, Antonella; Forsyth, Nicholas R.; Turnbull, Jeremy E.; Guerrini, Marco; Fernig, David G.; Yates, Edwin A.; Lima, Marcelo A.; Skidmore, Mark A.. . 'SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins'. arXiv. DOI > view in repository >
- Mycroft-West, Courtney J.; Su, Dunhao; Li, Yong; Guimond, Scott E.; Rudd, Timothy R.; Elli, Stefano; Miller, Gavin; Nunes, Quentin M.; Procter, Patricia; Bisio, Antonella; Forsyth, Nicholas R.; Turnbull, Jeremy E.; Guerrini, Marco; Fernig, David G.; Yates, Edwin A.; Lima, Marcelo A.; Skidmore, Mark A.. . 'Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain'. bioRxiv. DOI > view in repository >
- Davies, SP; Mycroft-West, CJ; Pagani, I; Hill, HJ; Chen, Y-H; Karlsson, R; Bagdonaite, I; Guimond, S; Stamataki, Z; Andrade De Lima, M; Turnbull, JE; Yang, Z; Vicenzi, E; Skidmore, M; Khanim, FL; Richardson, A. 06-08-2021. 'The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models.'. Frontiers in Pharmacology. DOI > view in repository >
- Mycroft-West, Courtney J.; Devlin, Anthony J.; Cooper, Lynsay C.; Guimond, Scott E.; Procter, Patricia; Guerrini, Marco; Miller, Gavin J.; Fernig, David G.; Yates, Edwin A.; Lima, Marcelo A.; Skidmore, Mark A.. 03-04-2021. 'Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer’s Disease ß Secretase, BACE1'. Marine Drugs. DOI > view in repository >
- Tree, JA; Turnbull, JE; Buttigieg, KR; Elmore, MJ; Coombes, N; Hogwood, J; Mycroft-West, CJ; Andrade De Lima, M; Skidmore, M; Karlsson, R; Chen, Y-H; Yang, Z; Spalluto, CM; Staples, KJ; Yates, EA; Gray, E; Singh, D; Wilkinson, T; Page, CP; Carroll, MW. 01-02-2021. 'Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations.'. British Journal of Pharmacology. DOI > view in repository >
- Devlin, A; Mycroft-West, C; Procter, P; Cooper, L; Guimond, S; Andrade De Lima, M; Yates, E; Skidmore, M. 25-09-2019. 'Tools for the Quality Control of Pharmaceutical Heparin.'. Medicina (Kaunas). DOI > view in repository >
- Mycroft-West, Courtney J.; Yates, Edwin A.; Skidmore, Mark A.. 20-08-2018. 'Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease'. Biochemical Society Transactions. DOI > view in repository >
- Skidmore, Mark A.; Kajaste-Rudnitski, Anna; Wells, Nicola M.; Guimond, Scott E.; Rudd, Timothy R.; Yates, Edwin A.; Vicenzi, Elisa. . 'Inhibition of influenza H5N1 invasion by modified heparin derivatives'. MedChemComm. DOI > view in repository >
- Mycroft-West, CJ; Devlin, AJ; Cooper, LC; Guimond, S; Procter, P; Miller, G; Guerrini, M; Fernig, DG; Yates, EA; Andrade De Lima, M; Skidmore, M. 01-03-2023. 'A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease ß-site amyloid precursor protein cleaving enzyme 1 (BACE-1).'. Carbohydrate Research. DOI > view in repository >
- Maciej-Hulme, Marissa L.; Leprince, Anaëlle C.N.; Lavin, Andre; Guimond, Scott E.; Turnbull, Jeremy E.; Pelletier, Julien; Yates, Edwin A.; Powell, Andrew K.; Skidmore, Mark A.. 02-02-2023. 'High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.'. Analytical Methods. DOI > view in repository >
- Devlin, Anthony J; Mycroft-West, Courtney J; Turnbull, Jeremy E; Andrade De Lima, Marcelo; Guerrini, Marco; Yates, Edwin A; Skidmore, Mark A. 01-02-2023. 'Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State.'. ACS Central Science. DOI > view in repository >
- Parafioriti, Michela; Ni, Minghong; Petitou, Maurice; Mycroft‐West, Courtney J.; Rudd, Timothy R.; Gandhi, Neha S.; Ferro, Vito; Turnbull, Jeremy E.; Andrade De Lima, Marcelo A.; Skidmore, Mark A.; Fernig, David G.; Bisio, Antonella; Guerrini, Marco; Yates, Edwin A.; Elli, Stefano. 02-01-2023. 'Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans.'. Chemistry. DOI > view in repository >
- Guimond, Scott; Mycroft-West, Courtney J.; Gandhi, Neha S.; Tree, Julia A.; C.Le, Thuy T.; Spalluto, Mirella; Humbert, Maria V.; Buttigieg, Karen R.; Coombes, Naomi; Elmore, Michael J.; Wand, Matthew; Nyström, Kristina; Said, Joanna; Setoh, Yin Xiang; Amarilla, Alberto A.; Modhiran, Naphak; Sng, Julian D. J.; Chhabra, Mohit; Young, Paul R.; Rawle, Daniel J.; Lima, Marcelo A.; Yates, Edwin A.; Karlsson, Richard; Miller, Rebecca L.; Chen, Yen-Hsi; Bagdonaite, Ieva; Yang, Zhang; Stewart, James; Nguyen, Dung; Laidlaw, Stephen; Hammond, Edward; Dredge, Keith; Wilkinson, Tom M. A.; Watterson, Daniel; Khromykh, Alexander A.; Suhrbier, Andreas; Carroll, Miles W.; Trybala, Edward; Bergström, Tomas; Ferro, Vito; Skidmore, Mark A.; Turnbull, Jeremy E.. 25-05-2022. 'Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.'. ACS Central Science. DOI > view in repository >
- Su, Dunhao; Li, Yong; Yates, Edwin; Skidmore, Mark; Andrade De Lima, Marcelo; Fernig, David. 08-04-2022. 'Analysis of protein-heparin interactions using a portable SPR instrument'. PeerJ Analytical Chemistry. DOI > view in repository >
- Schuurs, Zachariah P.; Hammond, Edward; Elli, Stefano; Rudd, Timothy R.; Mycroft-West, Courtney J.; Lima, Marcelo A.; Skidmore, Mark A.; Karlsson, Richard; Chen, Yen-Hsi; Bagdonaite, Ieva; Yang, Zhang; Ahmed, Yassir A.; Richard, Derek J.; Turnbull, Jeremy; Ferro, Vito; Coombe, Deirdre R.; Gandhi, Neha S.. 01-01-2021. 'Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain.'. Computational and Structural Biotechnology Journal. DOI > view in repository >
- Mycroft-West, Courtney J.; Su, Dunhao; Pagani , Isabel; Rudd , Timothy R.; Elli , Stefano; Gandhi , Neha S.; Guimond , Scott E.; Miller, Gavin J.; Meneghetti, Maria C.Z.; Nader, Helena B.; Li, Yong; Nunes, Quentin M.; Procter, Patricia; Mancini, Nicasio; Clementi, Massimo; Bisio, Antonella; Forsyth, Nicholas R.; Ferro, Vito; Turnbull , Jeremy E.; Guerrini , Marco; Fernig , David G.; Vicenzi , Elisa; Yates , Edwin A.; Lima , Marcelo A.; Skidmore , Mark A.. 23-12-2020. 'Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin.'. Thrombosis and Haemostasis. DOI > view in repository >
- Hyatt, James G.; Prévost, Sylvain; Devos, Juliette M.; Mycroft-West, Courtney J.; Skidmore, Mark A.; Winter, Anja. 11-11-2020. 'Molecular Changes in Dengue Envelope Protein Domain III upon Interaction with Glycosaminoglycans.'. Pathogens. DOI > view in repository >
- Mycroft-West, Courtney J.; Devlin, Anthony J.; Cooper, Lynsay C.; Procter, Patricia; Miller, Gavin J.; Fernig, David G.; Guerrini, Marco; Guimond, Scott E.; Lima, Marcelo A.; Yates, Edwin A.; Skidmore, Mark Andrew. 28-01-2020. 'Inhibition of BACE1, the ß-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus.'. Neural Regeneration Research. DOI > view in repository >
- Mycroft-West, CJ; Cooper, LC; Devlin, AJ; Procter, P; Guimond, SE; Guerrini, M; Fernig, DG; Lima, MA; Yates, EA; Skidmore, MA. 16-05-2019. 'A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease.'. Marine Drugs. DOI > view in repository >
- Maciej-Hulme, Marissa; Skidmore, Mark; Price, Helen. 20-08-2018. 'The role of heparan sulfate in host macrophage infection by Leishmania species'. Biochemical Society Transactions. DOI > view in repository >
- Holman, Joseph; Skidmore, Mark; Yates, Edwin. 27-04-2018. 'An Inexpensive, Pulsed, and Multiple Wavelength Bench-Top Light Source for Biological Spectroscopy'. Plasma. DOI > view in repository >
- Vicenzi, Elisa; Pagani, Isabel; Ghezzi, Silvia; Taylor, Sarah L.; Rudd, Timothy R.; Lima, Marcelo A.; Skidmore, Mark; Yates, Edwin A.. 20-04-2018. 'Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection'. Biochemical Society Transactions. DOI > view in repository >
- Rogerson, Evelyn; Pelletier, Julien; Acosta-Serrano, Alvaro; Rose, Clair; Taylor, Sarah; Guimond, Scott; Lima, Marcelo; Skidmore, Mark; Yates, Edwin. 19-03-2018. 'Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans'. Pathogens. DOI > view in repository >
- Kareem, N.; Yates, E.; Skidmore, M.; Hoole, D.. 01-03-2018. 'In vitro investigations on the effects of semi-synthetic, sulphated carbohydrates on the immune status of cultured common carp (Cyprinus carpio) leucocytes.'. Fish and Shellfish Immunology. DOI > view in repository >
- Skidmore, Mark; Mohd Fadzli Mustaffa, Khairul; Cooper, Lynsay C.; Guimond, Scott E.; Yates, Edwin A.; Craig, Alister G.. 18-10-2017. 'A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence'. PLoS One. DOI > view in repository >
- Boyle, Michelle J.; Skidmore, Mark; Dickerman, Benjamin; Cooper, Lynsay; Devlin, Anthony; Yates, Edwin; Horrocks, Paul; Freeman, Craig; Chai, Wengang; Beeson, James G.. 11-09-2017. 'Identification of heparin modifications and polysaccharide inhibitors of Plasmodium falciparum merozoite invasion that have potential for novel drug development.'. Antimicrobial Agents and Chemotherapy. DOI > view in repository >
- Ghezzi, Silvia; Cooper, Lynsay; Rubio, Alicia; Pagani, Isabel; Rosaria Capobianchi, Maria; Ippolito, Giuseppe; Pelletier, Julien; Meneghetti, Maria Cecilia Z.; Lima, Marcelo A.; Skidmore, Mark; Broccoli, Vania; Yates, Edwin A.; Vicenzi, Elisa. 05-01-2017. 'Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells'. Antiviral Research. DOI > view in repository >
- Lima, Marcelo A.; Cavalheiro, Renan P.; Viana, Gustavo M.; Meneghetti, Maria C.Z.; Rudd, Timothy R.; Skidmore, Mark; Powell, Andrew K.; Yates, Edwin A.. 15-08-2016. '19 F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy'. Glycoconjugate Journal. DOI > view in repository >
- Curtis, ADM; Malekigorji, M; Holman, J; Skidmore, M; Hoskins, C. 10-11-2015. 'Heat Dissipation of Hybrid Iron Oxide-Gold Nanoparticles in an Agar Phantom'. Journal of Nanomedicine and Nanotechnology. DOI > view in repository >
- Veraldi, N; Hughes, AJ; Rudd, TR; Thomas, HB; Edwards, SW; Hadfield, L; Skidmore, MA; Siligardi, G; Cosentino, C; Shute, JK; Naggi, A; Yates, EA. 06-03-2015. 'Heparin derivatives for the targeting of multiple activities in the inflammatory response.'. Carbohydr Polym. DOI > view in repository >
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Other
- Mycroft-West, Courtney J.; Su, Dunhao; Pagani, Isabel; Rudd, Timothy R.; Elli, Stefano; Guimond, Scott E.; Miller, Gavin; Meneghetti, Maria C. Z.; Nader, Helena B.; Li, Yong; Nunes, Quentin M.; Procter, Patricia; Mancini, Nicasio; Clementi, Massimo; Bisio, Antonella; Forsyth, Nicholas R.; Turnbull, Jeremy E.; Guerrini, Marco; Fernig, David G.; Vicenzi, Elisa; Yates, Edwin A.; Lima, Marcelo A.; Skidmore, Mark A.. . 'Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin'. . DOI > view in repository >
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Funding
Funding
Dr Skidmore’s current research grants include:
- Principal applicant and student supervisor: “Novel glycotherapeutics for Alzheimer's disease”. (Co-Is: Prof S Allin, Dr EA Yates, Dr MJ McKenzie, Dr P Horrocks) Medical Research Council industrial CASE studentship MR/J012246/1 with Charnwood Molecular Ltd, £109,288
- Co-applicant and co-author: “Novel semi-synthetic carbohydrates as potential therapeutics for severe malaria” (PI: Dr EA Yates) Medical Research Council £554,479
- Co-applicant and co-author: “Chemically modified low molecular weight heparins as potent disruptors of rosetting in severe malaria”. (PI: Dr EA Yates) Wellcome £59,769
- Collaborator : “Investigation into Plasmodium falciparum rosetting mechanisms and development of rosette-disrupting interventions to treat or prevent severe malaria”. PI Alex Rowe – Wellcome Trust Senior Research Fellowship.
School of Life Sciences,
Huxley Building,
Keele University,
Staffordshire,
ST5 5BG
Tel: +44 (0) 1782 734414
Enquiries:
Tel: +44 (0) 1782 734414
Email: lifesciences.office@keele.ac.uk