Dr Stuart Jenkins
- Title
- Lecturer in Neurobiology
- Location
- Huxley Building : 225
- Contact me
- Try my office, or arrange an appointment by email or phone
- Phone
- +44 (0)1782 733654
- s.i.jenkins@keele.ac.uk
Biography
Biography
Following degrees in Computer Science (University of Essex) and Biochemistry & Neuroscience (Keele), I earned my PhD in Biomedical Engineering, studying under Prof Divya Chari (Keele, 2013). During my PhD, I was awarded an EPSRC E-TERM Landscape Fellowship, also hosted in Prof Chari’s lab (2013-15). I then held a postdoc position with Dr David Morgan (Keele, School of Pharmacy; 2015-16), before becoming a Lecturer at Keele’s School of Medicine (Nov 2016-).
- PhD title: Applications of magnetic particles for oligodendrocyte precursor cell transplantation strategies
- Fellowship project, E-TERM (Engineering – Tissue Engineering and Regenerative Medicine; EP/I017801/1): Magnetically-assisted neuroengineering techniques
- Postdoc project: Investigating the roles of microglia in neurodegenerative disease and regenerative processes
Research and scholarship
Research and scholarship
I am interested in improving preclinical models of neurodegeneration in the central nervous system, particularly for screening nanomaterials with therapeutic potential for tissue engineering/regenerative medicine (TERM).
I mainly work with glial cells (astrocytes, oligodendrocytes, OPCs and microglia), but also embryonic stem cells (ESCs) and neurons (particularly dopaminergic).
I am associated with two themes at the Institute for Science and Technology in Medicine (ISTM):
I organised the ATREUM conference (3-6 April 2017) for early career researchers in Tissue Engineering and Regenerative Medicine (TERM)
In Feb 2014, I organised a Preclinical Modelling Workshop for Regenerative Medicine at Keele Hall.
I am a member of the British Neuroscience Association (BNA) and the British Society for Immunology (BSI).
Teaching
Teaching
I teach at Keele University Medical School, and am currently involved in curriculum development (MBChB).
Postgraduate Supervision:LSC-40043, MSc in Scientific Research Training
Further information
Further information
Links, Resources, News
- I am organising the ATREUM conference (3-6 April 2017) for early career researchers in Tissue Engineering and Regenerative Medicine (TERM)
- I coordinate the Brains for Breakfast (B4B) seminar series
School of Life Sciences, Huxley003, Weds 09:00-10:00
Informal seminars discussing recent and proposed research in Neuroscience-related subjects, including Computer Science.
Please contact me if you are interested in presenting, or would like to join the mailing list.
- I have contributed to the HEART (Healthcare Engineering & Regenerative Therapies) blog, aimed at teenagers interested in science
Are nanoparticles too small to be seen interacting with cells? [Jun 2014]
Can ‘stealth’ nanoparticles deliver medicine to the brain? [Apr 2014]
News, Events
- Drs Stuart Jenkins & Chris Adams appointed to Lectureships [Oct 2016]
- Teenagers in UK Science + Engineering Competition final [Feb 2016]
- Are nanoparticles too small to be seen interacting with cells? [Jun 2014]
- Can ‘stealth’ nanoparticles deliver medicine to the brain? [Apr 2014]
- Preclinical Modelling Workshop for Regenerative Medicine [Feb 2014]
- Cover image in prestigious publication [Jan 2014]
- Journal Cover Image for Dr Divya Chari and Dr Stuart Jenkins [Jul 2013]
- Dr Stuart Jenkins has been awarded an Engineering & Physical Sciences Research Council (EPSRC) Landscape Fellowship [Nov 2012]
- British Neuroscience Association Abstract Competition Winner [Jul 2012]
- ISTM student paper in top nanotechnology journal [Oct 2011]
Publications
Publications
Journal Articles
- Parwana, Krishma A. K.; Kaur Gill, Priyapreet; Njanike, Runyararo; Yiu, Humphrey H. P.; Adams, Chris F.; Chari, Divya Maitreyi; Jenkins, Stuart Iain. . 'Investigating Internalization of Reporter-Protein-Functionalized Polyhedrin Particles by Brain Immune Cells'. Materials. DOI > view in repository >
- Jenkins, S; Zhu, L; Dallas, M; Chen, R. 07-11-2022. 'Editorial: Neuroinflammation in hypoxia and ischaemia'. Frontiers in Molecular Biosciences. DOI > view in repository >
- Butcher, John; Sims, Robert; Ngum, Neville; Bazzari, Amjad H.; Jenkins, Stuart I.; King, Marianne; Hill, Eric J.; Nagel, David A.; Fox, Kevin; Rheinallt Parri, H.; Glazewski. 25-08-2022. 'A requirement for astrocyte IP3R2 signaling for whisker experience-dependent depression and homeostatic upregulation in the mouse barrel cortex.'. Frontiers in Cellular Neuroscience. DOI > view in repository >
- Basit, RH; Tzerakis, N; Jenkins, S; Chari, D M. 01-09-2021. 'In vitro model of traumatic brain injury to screen neuro-regenerative biomaterials'. Materials Science and Engineering: C. DOI > view in repository >
- Patabendige, A; Singh, A; Jenkins, S; Sen, J; Chen, R. 20-04-2021. 'Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke'. International Journal of Molecular Sciences. DOI > view in repository >
- Singh, A; Chow, O; Jenkins, S; Zhu, L; Rose, E; Astbury, K; Chen, R. 15-01-2021. 'characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons'. Neuroscience. DOI > view in repository >
- Rawlinson, C; Jenkins, S; Thei, L; Dallas, ML; Chen, R. 11-03-2020. 'Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy.'. Brain Sciences. DOI > view in repository >
- Mira, A; Codina, H; Jenkins, S; Rodriguez-Diaz, JC; Mallavia, R; Falco, A; Sainz-Urruela, C. 08-03-2020. 'Physico-Chemically Distinct Nanomaterials Synthesized from Derivates of a Poly(Anhydride) Diversify the Spectrum of Loadable Antibiotics.'. Nanomaterials. DOI > view in repository >
- Lim, J; Dobson, J; Subramanian, M; Miaskowski, A; Jenkins, S. 04-03-2019. 'Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death'. Applied Physics A-Materials Science & Processing. DOI > view in repository >
- Fricker, R; Green, E; Jenkins, S; Griffin, S. 21-05-2018. 'The Influence of Nicotinamide on Health and Disease in the Central Nervous System'. International Journal of Tryptophan Research. DOI > view in repository >
- Evans, MG; Shakli, A; Jenkins, S; Chari, D. 04-04-2017. 'Electrophysiological assessment of primary cortical neurons genetically engineered using iron oxide nanoparticles'. Nano Research. DOI > view in repository >
- Weightman, Alan P.; Jenkins, Stuart I.; Chari, Divya M.. 04-06-2016. 'Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake'. Nano Research. DOI > view in repository >
- Jenkins, S; Weinberg, D; Al-Shakli, A; Fernandes, A; Yiu, HHP; Telling, N; Roach, P; Chari, D. 28-02-2016. ''Stealth' nanoparticles evade neural immune cells but also evade all major brain cell populations: Implications for PEG-based neurotherapeutics'. J Control Release. DOI > view in repository >
- Tickle, JA; Jenkins, SI; Polyak, B; Pickard, MR; Chari, DM. 01-02-2016. 'Endocytotic potential governs magnetic particle loading in dividing neural cells: studying modes of particle inheritance.'. Nanomedicine. DOI > view in repository >
- Rafiq, Qasim A; Ortega, Ilida; Jenkins, Stuart I; Wilson, Samantha L; Patel, Asha K; Barnes, Amanda L; Adams, Christopher F; Delcassian, Derfogail; Smith, David. 01-11-2015. 'The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products'. Regenerative Medicine. DOI > view in repository >
- Tickle, Jacqueline A.; Jenkins, Stuart I.; Pickard, Mark R.; Chari, Divya M.. 01-03-2015. 'Influence of Amplitude of Oscillating Magnetic Fields on Magnetic Nanoparticle-Mediated Gene Transfer to Astrocytes'. NANO LIFE. DOI > view in repository >
- Jenkins, SI; Roach, P; Chari, DM. 01-01-2015. 'Development of a nanomaterial bio-screening platform for neurological applications'. Nanomedicine: Nanotechnology, Biology and Medicine. DOI > view in repository >
- Jenkins, S; Yiu, HH; Rosseinsky, MJ; Chari, D. 28-07-2014. 'Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges'. Molecular and Cellular Therapies. DOI > view in repository >
- Weightman, Alan; Jenkins, Stuart; Pickard, Mark; Chari, Divya; Yang, Ying. 01-02-2014. 'Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury'. Nanomedicine: Nanotechnology, Biology and Medicine. DOI > view in repository >
- Jenkins, SI; Pickard, MR; Khong, M; Smith, HL; Mann, CL; Emes, RD; Chari, DM. 15-01-2014. 'Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy'. ACS Chemical Neuroscience. DOI > view in repository >
- Jenkins, SI; Pickard, MR; Furness, DN; Yiu, HH; Chari, DM. 01-06-2013. 'Differences in magnetic particle uptake by CNS neuroglial subclasses: implications for neural tissue engineering'. Nanomedicine. DOI > view in repository >
- Nutt, Kayleigh; Dombros-Ryan, Zoe; Birea, Ruxandra; Franks, Emily Victoria; Eastham, Sarah; Godwin, Morgan; Adams, Chris F.; Chari, Divya Maitreyi; Jenkins, Stuart Iain. . 'Electrospun Polycaprolactone (PCL) Nanofibers Induce Elongation and Alignment of Co-Cultured Primary Cortical Astrocytes and Neurons'. Micromachines. DOI > view in repository >
- Hollingworth, Bethany Y. A.; Pallier, Patrick N.; Jenkins, Stuart I.; Chen, Ruoli. . 'Hypoxic Neuroinflammation in the Pathogenesis of Multiple Sclerosis'. Brain Sciences. DOI > view in repository >
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Book Chapter
- Jenkins, SI; Chari, DM. 05-01-2018. 'A Stoichiometrically Defined Neural Coculture Model to Screen Nanoparticles for Neurological Applications'. . DOI > view in repository >
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Gallery
Gallery
- Three of my publications have featured as journal covers
- Videos, produced using time-lapse fluorescence microscopy
Fluorescent magnetic nanoparticles being internalised by brain cells
PhD Students
PhD Students
Lab members, opportunities
- Emma Green, PhD student (2016-)
Vitamin driven generation of dopaminergic neurons as cell replacement therapy for Parkinson’s disease
- Michael Santer, MSc Scientific Research Training (2016-)
Serum-free media for neural cell culture
- Shida “Tiggs” Gholamian, Keele medical student, INSPIRE Summer Studentship (2016, with Dr David Morgan)
Eight week project: “Does repeated activation generate an ‘experienced’ microglial phenotype, with altered pro-inflammatory responses?”
- Anna Biju, Nuffield Research Placement (2016, with Dr David Morgan)
Anna Biju won a place in the national finals of the National Science + Engineering Competition (British Science Association, BSA), presenting our work at The Big Bang Fair. Covered in The Sentinel.
- Students wanted:
I welcome applications to undertake postgraduate (PhD or MPhil) studies in my laboratory. Please contact me directly (s.i.jenkins@keele.ac.uk) to discuss potential projects and the application process. See the "Research and Scholarship" tab for my research interests.
School of Life Sciences,
Huxley Building,
Keele University,
Staffordshire,
ST5 5BG
Tel: +44 (0) 1782 734414
Enquiries:
Tel: +44 (0) 1782 734414
Email: lifesciences.office@keele.ac.uk