SCIATIC |
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Chief Investigator: |
Dr Nefyn Williams (Bangor) |
Co-applicants: |
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Principal Investigator: |
NIHR Prof Nadine Foster |
Study Co-ordinator: |
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Funder name / reference no: |
HTA 12/201/02 |
MREC number: |
15/WA/0105 |
EudraCT number: |
2015-000636-15 |
ISRCTN: |
N/A |
UKCRN Study portfolio: |
18417 |
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Summary of trial: |
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Trial Objectives:
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Trial Design: Multi-centre randomised controlled trial (RCT) of 332 participants recruited from primary care or musculoskeletal services with a concurrent economic evaluation and an internal pilot trial. |
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Treatments: All participants will be randomised to receive two doses of subcutaneous injection two weeks apart. The intervention group will receive 80mg adalimumab followed by 40mg [21] in order to administer a therapeutic dose of adalimumab for a period of four weeks. The control group will receive an equivalent volume of 0.9% Sodium Chloride as the intervention group. All participants will also have a course of physiotherapy. |