
Dr Ivonne Solis-Trapala
- Title
- Reader in Biostatistics and Keele CTU Director
- Location
- DJW 1.62
- Contact me
- Via email
- Phone
- +44 (0) 1782 734711
- i.solis-trapala@keele.ac.uk
Biography
Biography
I am a Reader in Biostatistics and the Director of Keele Clinical Trials Unit (CTU), a fully registered UKCRC Clinical Trials Unit. I am passionate about improving health outcomes through rigorous research. In my role, I provide strategic leadership for the CTU, overseeing a diverse portfolio of clinical trials and large cohort studies, supported by a multidisciplinary team. My expertise includes advanced statistical methods such as graphical models and multistate modelling, which I apply across various fields including health services research, oncology, and global mental health.
I also serve as Co-Director of the NIHR Research Support Service Hub, delivered by the University of Birmingham and Partners. In this role, I offer leadership and expert guidance for health and care research across England. Since 2023, I have contributed as a subject matter expert to the World Health Organization's GSED project, helping develop global measures for early childhood development evaluation.
Additionally, I am an expert member of the NIHR Health Technology Assessment Commissioning Funding Committee. I chair or sit on several external Trial Steering Committees and Data Monitoring Committees for national randomised clinical trials.
I obtained a PhD in Statistics from the University of Cambridge and held a four-year MRC Fellowship in Biostatistics at Lancaster. Before joining Keele, I led the biostatistics team at MRC Human Nutrition Research in Cambridge.
Research and scholarship
Research and scholarship
My research focuses on applying state-of-the-art statistical methodology, including graphical modelling, which utilises causal graphs to represent causal associations, multistate modelling for the analysis of time-to-event data, and clinical trials methodology. Collaboratively, I work across various fields, such as health services research, psycho-oncology, and global mental health.
Drawing upon my expertise on graphical models, acquired during an MRC Fellowship in Biostatistics held at Lancaster University, I have pioneered the application of the “sequences of regressions” graphical model for the analysis of complex data such as real-world evidence, clinical trials, and registry data. For example, in Lawson et al (2018, PLOS Medicine, DOI:10.1371/journal.pmed.1002540), I led the development of a causal graph depicting the relative impact of a patient's cardiovascular (CV) and non-CV comorbidities on quality of life in patients with heart failure, using data from the Swedish Heart Failure Register. We demonstrated that non-CV comorbidities can significantly outweigh CV conditions in their impact on patients' quality of life. This insight has contributed to enhancing care for patients with heart failure (Heart Failure Policy Network, 2022).
In the field of renal research, I have overseen the conduct of a randomised controlled trials for complex interventions and introduced a novel approach utilising both graphical and multistate modelling for the analysis and interpretation of real-world mixed-methods studies. These contributions have attracted significant external grant income (including the £1.1 million NIHR-funded Inter-CEPt study, award ID: NIHR128364) and resulted in publications featured in world-leading journals (e.g., Kidney International (2023, DOI:10.1016/j.kint.2023.05.016 and Kidney International Reports (2023, DOI:10.1016/j.ekir.2023.09.015)) which will positively impact clinical practice and improve patient outcomes.
In collaboration with Professors Fallowfield and Jenkins (University of Sussex), I have established a strong track record in generating clinical trial evidence on the efficacy of educational programmes focused on communication skills for healthcare professionals. Our work has informed policy and been adopted worldwide.
Since 2023, I have been a subject matter expert for the World Health Organization working group that developed the Global Scale for Early Development (GSED) tool for use in population monitoring and programmatic evaluation of early childhood development. We are currently evaluating the psychometric properties of the tool in new populations and establishing global norms and standards.
I have been the principal investigator or co-investigator of external grants totalling over £29 million from NIHR, MRC, ESRC, Horizon 2020 EU Marie Skłodowska-Curie, and the Bill & Melinda Gates Foundation.
Teaching
Teaching
I lead and co-supervise PhD students in Biostatistics and Medical Sciences as well as MPhil and Medical Doctoral students.
Further information
Further information
I am a fellow of the Royal Statistical Society, a member of the International Biometric Society, British and Irish region, and a member of the International Society for Clinical Biostatistics.
I review for leading peer-reviewed journals (including New England Journal of Medicine, BMJ, Nature Communications, Biostatistics and Statistics in Medicine) and multiple grant funding bodies including the Medical Research Council, the National Institute for Health and Care Research, the Economic and Social Research Council and the Engineering and Physical Sciences Research Council.
Publications
Publications
Journal Articles
- Johal, Neena; Sharma, Radha; Belcher, John; Coyle, David; Lindley, Elizabeth J.; Keane, David; Caskey, Fergus J.; Dasgupta, Indranil; Davenport, Andrew; Farrington, Ken; Mitra, Sandip; Ormandy, Paula; Wilkie, Martin; Macdonald, Jamie; Solis-Trapala, Ivonne; Sim, Julius; Davies, Simon J.. 06-11-2024. 'Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients'. BMC Nephrology. DOI > view in repository >
- Belcher, John; Coyle, David; Lindley, Elizabeth J; Keane, David; Caskey, Fergus J; Dasgupta, Indranil; Davenport, Andrew; Farrington, Ken; Mitra, Sandip; Ormandy, Paula; Wilkie, Martin; Macdonald, Jamie; Hugo Macdonald, Jamie; Solis-Trapala, Ivonne; Sim, Julius; Davies, Simon J. 10-10-2024. 'Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial'. Kidney360. DOI > view in repository >
- Zanganeh, Mandana; Belcher, John; Fotheringham, James; Coyle, David; Lindley, Elizabeth J; Keane, David F; Caskey, Fergus J; Dasgupta, Indranil; Davenport, Andrew; Farrington, Ken; Mitra, Sandip; Ormandy, Paula; Wilkie, Martin; Macdonald, Jamie H; Solis-Trapala, Ivonne; Sim, Julius; Davies, Simon J; Andronis, Lazaros. 01-09-2024. 'Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT'. Health Technology Assessment. DOI > view in repository >
- Damery, Sarah; Lambie, Mark; Williams, Iestyn; Coyle, David; Fotheringham, James; Solis-Trapala, Ivonne; Allen, Kerry; Potts, Jessica; Dikomitis, Lisa; Davies, Simon J. 01-07-2024. 'Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England'. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis. DOI > view in repository >
- Toader, Alice-Maria; Campbell, Marion K.; Quint, Jennifer K.; Robling, Michael; ydes, Matthew R.; Thorn, Joanna; Wright-Hughes, Alexandra; Yu, Ly-Mee; Abbott, Tom E. F.; Bond, Simon; Caskey, Fergus J.; Clout, Madeleine; Collinson, Michelle; Copsey, Bethan; Davies, Gwyneth; Driscoll, Timothy; Gamble, Carrol; Griffin, Xavier L.; Hamborg, Thomas; Harris, Jessica; Harrison, David A.; Harji, Deena; Henderson, Emily J.; Logan, Pip; Love, Sharon B.; Magee, Laura A.; O’Brien, Alastair; Pufulete, Maria; Ramnarayan, Padmanabhan; Saratzis, Athanasios; Smith, Jo; Solis-Trapala, Ivonne; Stubbs, Clive; Farrin, Amanda; Williamson, Paula. 29-01-2024. 'Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage'. Trials. DOI > view in repository >
- Davies, Simon J.; Coyle, David; Lindley, Elizabeth J.; Keane, David; Belcher, John; Caskey, Fergus J.; Dasgupta, Indranil; Davenport, Andrew; Farrington, Ken; Mitra, Sandip; Ormandy, Paula; Wilkie, Martin; Macdonald, Jamie; Zanganeh, Mandana; Andronis, Lazaros; Solis-Trapala, Ivonne; Sim, Julius. 01-01-2023. 'Bio-impedance spectroscopy added to a fluid management protocol does not improve preservation of residual kidney function in incident hemodialysis patients in a randomized controlled trial'. Kidney International. DOI > view in repository >
- Shilling, Val; Jenkins, Valerie; Solis Trapala, Ivonne. 01-01-2006. 'The (mis)classification of chemo-fog – methodological inconsistencies in the investigation of cognitive impairment after chemotherapy'. Breast Cancer Research and Treatment. DOI > view in repository >
- Prior, James A; Roddy, Edward; Solis-Trapala, Ivonne; Cornwall, Nicola; Jinks, Clare; Abhishek, Abhishek; Bukhari, Marwan; Galloway, James; Goodson, Nicola; Jowett, Sue; Hider, Samantha. . 'How do clinicians prescribe bridging glucocorticoids in people starting or escalating disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a service evaluation survey'. Rheumatology Advances in Practice. DOI > view in repository >
- Istanbuly, Obaida; Belcher, John; Tabinor, Matthew; Solis-Trapala, Ivonne; Lambie, Mark; Davies, Simon J. . 'Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis'. BMC Nephrology. DOI > view in repository >
- Jenkins, Valerie; Matthews, L; Solis-Trapala, I; Gage, H; May, S; Williams, P; Bloomfield, D; Zammit, C; Elwell-Sutton, D; Betal, D; Finlay, J; Nicholson, K; Kothari, M; Santos, R; Stewart, E; Bell, S; McKinna, F; Teoh, M. 01-10-2023. 'Patients’ experiences of a suppoRted self-manAGeMent pAThway In breast Cancer (PRAGMATIC): quality of life and service use results'. Supportive Care in Cancer. DOI > view in repository >
- Fotheringham, James; Solis-Trapala, Ivonne; Briggs, Victoria; Lambie, Mark; McCullough, Keith; Dunn, Louese; Rawdin, Andrew; Hill, Harry; Wailloo, Allan; Davies, Simon; Wilkie, Martin. 17-09-2023. 'Catheter Event Rates in Medical Compared to Surgical Peritoneal Dialysis Catheter Insertion'. Kidney International Reports. DOI > view in repository >
- Solis-Trapala, Ivonne; Campbell, P.; Lacey, R.J.; Rowlands, G.; Dunn, K.M.; Protheroe, Joanne. 01-09-2023. 'Are childhood factors predictive of adult health literacy? A longitudinal birth cohort analysis'. SSM - Population Health. DOI > view in repository >
- Gilchrist, Francis; Aspey, Mathew; Bowler, Robert; Brodlie, Malcolm; Desai, Seema; Harris, Caroline; Hinton, Emily; Kulkarni, Hemant; Ogbolosingha, Aviva; Sinha, Ian; Solis-Trapala, Ivonne; Stock, Joanne; Carroll, William D. 21-11-2022. 'Protocol for CLASSIC PBB: comparison of lower airway sampling strategies in children with protracted bacterial bronchitis'. BMJ Paediatrics Open. DOI > view in repository >
- Fallowfield, Lesley; Solis-Trapala; Solis-Trapala, Ivonne; Starkings, Rachel; May, Shirley; Matthews, Lucy; Eccles, Diana; Evans, D. Gareth; Turnbull, Clare; Crawford, Gillian; Jenkins, Valerie. 05-10-2022. 'Talking about Risk, UncertaintieS of Testing IN Genetics (TRUSTING): development and evaluation of an educational programme for healthcare professionals about BRCA1 & BRCA2 testing'. British Journal of Cancer. DOI > view in repository >
- Tshimologo, Maatla; Allen, Kerry; Coyle, David; Damery, Sarah; Dikomitis, Lisa; Fotheringham, James; Hill, Harry; Lambie, Mark; Phillips-Darby, Louise; Solis-Trapala, Ivonne; Williams, Iestyn; Davies, Simon. 01-06-2022. 'Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle'. BMJ Open. DOI > view in repository >
- Boyer, Annabel; Solis-Trapala, Ivonne; Tabinor, Matthew; Lambie, Mark; Davies, Simon. 01-09-2020. 'Impact of the implementation of an assisted peritoneal dialysis service on peritoneal dialysis initiation'. Nephrology Dialysis Transplantation. DOI > view in repository >
- Fallowfield, L.; Solis-Trapala, I.; Starkings, R.; Catt, S.; May, S.; Jenkins, V.. 01-10-2019. 'Talking About Risk in the Context of GEnomic Tests (TARGET): Development and evaluation of an educational program for clinicians'. Breast Cancer Research and Treatment. DOI > view in repository >
- Lambie, Mark; Teece, Lucy; Johnson, David W; Petrie, Michaela; Mactier, Robert; Solis-Trapala, Ivonne; Belcher, John; Bekker, Hilary L; Wilkie, Martin; Tupling, Ken; Phillips-Darby, Louise; Davies, Simon J. 01-02-2019. 'Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death'. Nephrology Dialysis Transplantation. DOI > view in repository >
- Jenkins, V.; Solis-Trapala, I.; Payne, H.; Mason, M.; Fallowfield, L.; May, S.; Matthews, L.; Catt, S.. 01-02-2019. 'Treatment Experiences, Information Needs, Pain and Quality of Life in Men with Metastatic Castrate-resistant Prostate Cancer: Results from the EXTREQOL Study'. Clinical Oncology. DOI > view in repository >
- Duff, Christopher J.; Solis-Trapala, Ivonne; Driskell, Owen J.; Holland, David; Wright, Helen; Waldron, Jenna L.; Ford, Clare; Scargill, Jonathan J.; Tran, Martin; Hanna, Fahmy W.F.; Pemberton, R. John; Heald, Adrian; Fryer, Anthony A.. 02-10-2018. 'The frequency of testing for glycated haemoglobin, HbA1c, is linked to the probability of achieving target levels in patients with suboptimally controlled diabetes mellitus.'. Clinical Chemistry and Laboratory Medicine. DOI > view in repository >
- Solis-Trapala. 04-07-2018. 'Greater improvements in diet quality among overweight participants following a group-based commercial weight loss programme than those receiving support to lose weight in primary care'. Nutrition Journal. DOI > view in repository >
- Briggs, Victoria; Solis-Trapala, Ivonne; Wailloo, Allan; McCulloch, Keith; Lambie, Mark; Caskey, Fergus; Fotheringham, James; Davies, Simon; Wilkie, Martin. 01-07-2018. 'United Kingdom Catheter Study – Protocol Synopsis'. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis. DOI > view in repository >
- Mamas; Solis-Trapala. 27-03-2018. 'Comorbidity health pathways in heart failure patients: A sequences-of-regressions analysis using cross-sectional data from 10,575 patients in the Swedish Heart Failure Registry'. PLoS Medicine. DOI > view in repository >
- Briggs, Victoria; Solis-Trapala, Ivonne; Wailloo, Allan; McCulloch, Keith; Lambie, Mark; Caskey, Fergus; Fotheringham, James; Davies, Simon; Wilkie, Martin. 01-03-2018. 'United Kingdom Catheter Study - Protocol Synopsis.'. Peritoneal Dialysis International. DOI > view in repository >
- Davie, SJ; Coyle, D; Dasgupta, I; Andronis, L; Farrington, K; Wilkie, M; Mitra, S; Ormandy, P; Lindley, E; Macdonald, J; Solis-Trapala, I; Sim, J; Davenport, A; Caskey, FJ. 26-04-2017. 'Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients'. BMC Nephrology. DOI > view in repository >
- Solis-Trapala. 21-03-2017. 'The effect of ovarian cancer screening on sexual activity and functioning: results from the UK collaborative trial of ovarian cancer screening RCT'. British Journal of Cancer. DOI > view in repository >
- Solis-Trapala. 15-12-2016. 'Acceptability and potential effectiveness of commercial portion control tools amongst people with obesity'. British Journal of Nutrition. DOI > view in repository >
- Almiron-Roig, Eva; Domínguez, Angélica; Vaughan, David; Solis-Trapala, Ivonne; Jebb, Susan A.. 01-11-2016. 'Acceptability, ease of use and perceived effectiveness of two portion control tools by people who are obese'. Proceedings of the Nutrition Society. DOI > view in repository >
- Solis-Trapala. 01-07-2016. 'A simplified approach to estimating the distribution of occasionally-consumed dietary components, applied to alcohol intake'. BMC Medical Research Methodology. DOI > view in repository >
- Solis-Trapala. 09-03-2016. 'Sequences of Regressions Distinguish Nonmechanical from Mechanical Associations between Metabolic Factors, Body Composition, and Bone in Healthy Postmenopausal Women'. The Journal of Nutrition. DOI > view in repository >
- Walker, Celia G.; Solis-Trapala, Ivonne; Holzapfel, Christina; Ambrosini, Gina L.; Fuller, Nicholas R.; Loos, Ruth J.F.; Hauner, Hans; Caterson, Ian D.; Jebb, Susan A.. 08-07-2015. 'Modelling the Interplay between Lifestyle Factors and Genetic Predisposition on Markers of Type 2 Diabetes Mellitus Risk'. PLoS One. DOI > view in repository >
- Lewis, Hannah B.; Ahern, Amy L.; Solis-Trapala, Ivonne; Walker, Celia G.; Reimann, Frank; Gribble, Fiona M.; Jebb, Susan A. 05-06-2015. 'Effect of reducing portion size at a compulsory meal on later energy intake, gut hormones, and appetite in overweight adults.'. Obesity (Silver Spring). DOI > view in repository >
- Solis-Trapala. 19-02-2015. 'Post-operative exercises after breast cancer surgery: Results of a RCT evaluating standard care versus standard care plus additional yoga exercise'. European Journal of Integrative Medicine. DOI > view in repository >
- Solis-Trapala. 18-11-2014. 'Large portion sizes increase bite size and eating rate in overweight women.'. Physiol Behav. DOI > view in repository >
- E, Almiron-Roig; I, Solis-Trapala; J, Dodd; SA, Jebb. 01-12-2013. 'Estimating food portions. Influence of unit number, meal type and energy density.'. Appetite. DOI > view in repository >
- Jenkins, V; Catt, S; Banerjee, S; Gourley, C; Montes, A; Solis-Trapala, I; Monson, K; Fallowfield, L. 11-06-2013. 'Patients' and oncologists' views on the treatment and care of advanced ovarian cancer in the U.K.: results from the ADVOCATE study'. British Journal of Cancer. DOI > view in repository >
- R, Simcock; L, Fallowfield; K, Monson; I, Solis-Trapala; L, Parlour; C, Langridge; V, Jenkins; Steering Committee, ARIX. 01-03-2013. 'ARIX: a randomised trial of acupuncture v oral care sessions in patients with chronic xerostomia following treatment of head and neck cancer.'. Annals of Oncology. DOI > view in repository >
- Lobban, Fiona; Solis-Trapala, Ivonne; Tyler, Elizabeth; Chandler, Claire; Morriss, Richard Keith; Group, ERP. 01-01-2013. 'The role of beliefs about mood swings in determining outcome in bipolar disorder'. Cognitive Therapy and Research. DOI > view in repository >
- Todd, Nicholas J.; Solis-Trapala, Ivonne; Jones, Steven H.; Lobban, Fiona A.. 01-07-2012. 'An online randomised controlled trial to assess the feasibility, acceptability and potential effectiveness of “Living with Bipolar”: A web-based self-management intervention for Bipolar Disorder: Trial design and protocol'. Contemporary Clinical Trials. DOI > view in repository >
- LJ, Fallowfield; I, Solis-Trapala; VA, Jenkins. 01-01-2012. 'Evaluation of an educational program to improve communication with patients about early-phase trial participation.'. . DOI > view in repository >
- Solis-Trapala. 02-09-2011. 'The views of patients and the general public about expensive anti-cancer drugs in the NHS: a questionnaire-based study.'. JRSM Short Reports. DOI > view in repository >
- Bartolucci, Francesco; Solis-Trapala, Ivonne L.. 01-01-2010. 'Multidimensional latent markov models in a developmental study of inhibitory control and attentional flexibility in early childhood'. Psychometrika. DOI > view in repository >
- Solis-Trapala, I.L.; Farewell, V.T.. 01-08-2005. 'Regression analysis of overdispersed correlated count data with subject specific covariates.'. . DOI > view in repository >
- Jenkins, V; Fallowfield, L; Solis-Trapala, I; Langridge, C; Farewell, V. 10-02-2005. 'Discussing randomised clinical trials of cancer therapy: evaluation of a Cancer Research UK training programme'. BMJ. DOI > view in repository >
- L, Fallowfield; V, Jenkins; V, Farewell; I, Solis-Trapala. 01-10-2003. 'Enduring impact of communication skills training: results of a 12-month follow-up.'. British Journal of Cancer. DOI > view in repository >
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Conference Proceeding
- Cheung, C.; Kasraie, J.; Solis-Trapala, I.; Sizer, A.. 09-07-2020. 'Comparison of perinatal outcomes between day 5 and 6 blastocyst transfers in both fresh and frozen cycles'. . view in repository >
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Digital Artefact
- Solis-Trapala, Ivonne. 02-05-2019. 'multinbmod-package: Regression analysis of overdispersed correlated count data'. . view in repository >
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Presentation / Conferences
- Fallowfield, Lesley; Solis-Trapala, Ivonne; Starkings, Rachel; Matthews, Lucy; May, Shirley; Jenkins, Valerie A. . 'Improving patient understanding of GEP test results (IMPARTER4): An RCT.'. . DOI > view in repository >
- Tabinor, Matthew; Potts, Jessica; Ferro, Charles J; Davies, Simon; Solis-Trapala, Ivonne. . '#1248 Sex specific associations between fat free mass and weight with mortality: sequences of regressions analyses from the UK Biobank cohort'. . DOI > view in repository >
- Tabinor, Matthew; Potts, Jessica; Ferro, Charles J; Davies, Simon; Solis-Trapala, Ivonne. . '#2796 Divergent associations between mortality and different measures of renal function after adjustment for body composition: results from the UK Biobank'. . DOI > view in repository >
- Tabinor, Matthew; Elphick, Emma; Stephens, Charlotte; Wall, Nadya; Ul Hussain, Azm; Shah, Rafeea; Peracha, Javeria; Anderson, Benjamin; Istanbuly, Obaida; Solis-Trapala, Ivonne; Ferro, Charles J; Davies, Simon. . '#2832 Lean tissue mass is associated with mortality across different stages of chronic kidney disease: a systematic review and meta-analysis'. . DOI > view in repository >
- Davies, Simon J.; Zanganeh, Mandana; Solis-Trapala, Ivonne; Keane, David F.; Davenport, Andrew; Wilkie, Martin E.; Ormandy, Paula; Macdonald, Jamie H.; Dasgupta, Indranil; Farrington, Ken; Caskey, Fergus. . 'The Bioimpedance Spectroscopy to Preserve Renal Output (BISTRO) Multicentre Randomised Controlled Trial: Quality of Life and Blood Pressure Outcomes'. . DOI > view in repository >
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