Dr Scott Guimond
- Title
- Lecturer in Bioscience
- Location
- Keele University School of Medicine, David Weatherall building, Keele campus, ST5 5BG
- Role
- Teacher in UG Medicine
- Contact me
- Via tel or email
- Phone
- 01782 734663
- s.e.guimond@keele.ac.uk
Publications
Publications
Journal Articles
- Mycroft-West, Courtney; Su, Dunhao; Elli, Stefano; Li, Yong; Guimond, Scott; Miller, Gavin; Turnbull, Jeremy; Yates, Edwin; Guerrini, Marco; Fernig, David; Lima, Marcelo; Skidmore, Mark. 01-01-2020. 'The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding'. . DOI > view in repository >
- Mycroft-West, Courtney J.; Su, Dunhao; Li, Yong; Guimond, Scott E.; Rudd, Timothy R.; Elli, Stefano; Miller, Gavin; Nunes, Quentin M.; Procter, Patricia; Bisio, Antonella; Forsyth, Nicholas R.; Turnbull, Jeremy E.; Guerrini, Marco; Fernig, David G.; Yates, Edwin A.; Lima, Marcelo A.; Skidmore, Mark A.. . 'SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins'. arXiv. DOI > view in repository >
- Mycroft-West, Courtney J.; Su, Dunhao; Li, Yong; Guimond, Scott E.; Rudd, Timothy R.; Elli, Stefano; Miller, Gavin; Nunes, Quentin M.; Procter, Patricia; Bisio, Antonella; Forsyth, Nicholas R.; Turnbull, Jeremy E.; Guerrini, Marco; Fernig, David G.; Yates, Edwin A.; Lima, Marcelo A.; Skidmore, Mark A.. . 'Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain'. bioRxiv. DOI > view in repository >
- Mycroft-West, CJ; Devlin, AJ; Cooper, LC; Guimond, S; Procter, P; Miller, G; Guerrini, M; Fernig, DG; Yates, EA; Andrade De Lima, M; Skidmore, M. 01-03-2023. 'A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease ß-site amyloid precursor protein cleaving enzyme 1 (BACE-1).'. Carbohydrate Research. DOI > view in repository >
- Maciej-Hulme, Marissa L.; Leprince, Anaëlle C.N.; Lavin, Andre; Guimond, Scott E.; Turnbull, Jeremy E.; Pelletier, Julien; Yates, Edwin A.; Powell, Andrew K.; Skidmore, Mark A.. 02-02-2023. 'High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.'. Analytical Methods. DOI > view in repository >
- Guimond, Scott; Mycroft-West, Courtney J.; Gandhi, Neha S.; Tree, Julia A.; C.Le, Thuy T.; Spalluto, Mirella; Humbert, Maria V.; Buttigieg, Karen R.; Coombes, Naomi; Elmore, Michael J.; Wand, Matthew; Nyström, Kristina; Said, Joanna; Setoh, Yin Xiang; Amarilla, Alberto A.; Modhiran, Naphak; Sng, Julian D. J.; Chhabra, Mohit; Young, Paul R.; Rawle, Daniel J.; Lima, Marcelo A.; Yates, Edwin A.; Karlsson, Richard; Miller, Rebecca L.; Chen, Yen-Hsi; Bagdonaite, Ieva; Yang, Zhang; Stewart, James; Nguyen, Dung; Laidlaw, Stephen; Hammond, Edward; Dredge, Keith; Wilkinson, Tom M. A.; Watterson, Daniel; Khromykh, Alexander A.; Suhrbier, Andreas; Carroll, Miles W.; Trybala, Edward; Bergström, Tomas; Ferro, Vito; Skidmore, Mark A.; Turnbull, Jeremy E.. 25-05-2022. 'Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.'. ACS Central Science. DOI > view in repository >
- Davies, SP; Mycroft-West, CJ; Pagani, I; Hill, HJ; Chen, Y-H; Karlsson, R; Bagdonaite, I; Guimond, S; Stamataki, Z; Andrade De Lima, M; Turnbull, JE; Yang, Z; Vicenzi, E; Skidmore, M; Khanim, FL; Richardson, A. 06-08-2021. 'The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models.'. Frontiers in Pharmacology. DOI > view in repository >
- Mycroft-West, Courtney J.; Devlin, Anthony J.; Cooper, Lynsay C.; Guimond, Scott E.; Procter, Patricia; Guerrini, Marco; Miller, Gavin J.; Fernig, David G.; Yates, Edwin A.; Lima, Marcelo A.; Skidmore, Mark A.. 03-04-2021. 'Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer’s Disease ß Secretase, BACE1'. Marine Drugs. DOI > view in repository >
- Mycroft-West, Courtney J.; Su, Dunhao; Pagani , Isabel; Rudd , Timothy R.; Elli , Stefano; Gandhi , Neha S.; Guimond , Scott E.; Miller, Gavin J.; Meneghetti, Maria C.Z.; Nader, Helena B.; Li, Yong; Nunes, Quentin M.; Procter, Patricia; Mancini, Nicasio; Clementi, Massimo; Bisio, Antonella; Forsyth, Nicholas R.; Ferro, Vito; Turnbull , Jeremy E.; Guerrini , Marco; Fernig , David G.; Vicenzi , Elisa; Yates , Edwin A.; Lima , Marcelo A.; Skidmore , Mark A.. 23-12-2020. 'Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin.'. Thrombosis and Haemostasis. DOI > view in repository >
- Ní Cheallaigh, Aisling; Guimond, Scott; Oscarson, Stefan; Miller, Gavin. 01-09-2020. 'Chemical synthesis of a sulfated d-glucosamine library and evaluation of cell proliferation capabilities.'. Carbohydrate Research. DOI > view in repository >
- Miller, Rebecca L.; Guimond, Scott E.; Schwörer, Ralf; Zubkova, Olga V.; Tyler, Peter C.; Xu, Yongmei; Liu, Jian; Chopra, Pradeep; Boons, Geert-Jan; Grabarics, Márkó; Manz, Christian; Hofmann, Johanna; Karlsson, Niclas G.; Turnbull, Jeremy E.; Struwe, Weston B.; Pagel, Kevin. 20-03-2020. 'Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides'. Nature Communications. DOI > view in repository >
- Mycroft-West, Courtney J.; Devlin, Anthony J.; Cooper, Lynsay C.; Procter, Patricia; Miller, Gavin J.; Fernig, David G.; Guerrini, Marco; Guimond, Scott E.; Lima, Marcelo A.; Yates, Edwin A.; Skidmore, Mark Andrew. 28-01-2020. 'Inhibition of BACE1, the ß-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus.'. Neural Regeneration Research. DOI > view in repository >
- Devlin, A; Mycroft-West, C; Procter, P; Cooper, L; Guimond, S; Andrade De Lima, M; Yates, E; Skidmore, M. 25-09-2019. 'Tools for the Quality Control of Pharmaceutical Heparin.'. Medicina (Kaunas). DOI > view in repository >
- Mycroft-West, CJ; Cooper, LC; Devlin, AJ; Procter, P; Guimond, SE; Guerrini, M; Fernig, DG; Lima, MA; Yates, EA; Skidmore, MA. 16-05-2019. 'A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease.'. Marine Drugs. DOI > view in repository >
- Chanalaris, Anastasios; Clarke, Hannah; Guimond, Scott E.; Vincent, Tonia L.; Turnbull, Jeremy E.; Troeberg, Linda. 01-03-2019. 'Heparan Sulfate Proteoglycan Synthesis Is Dysregulated in Human Osteoarthritic Cartilage'. The American Journal of Pathology. DOI > view in repository >
- Zubkova, Olga V.; Ahmed, Yassir A.; Guimond, Scott E.; Noble, Sophia-Louise; Miller, John Holmes; Alfred Smith, Raymond Alexander; Nurcombe, Victor; Tyler, Peter C.; Weissmann, Marina; Vlodavsky, Israel; Turnbull, Jeremy E.. 21-12-2018. 'Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy'. ACS Chemical Biology. DOI > view in repository >
- Miller, Rebecca L.; Guimond, Scott E.; Prescott, Mark; Turnbull, Jeremy E.; Karlsson, Niclas. 05-09-2017. 'Versatile Separation and Analysis of Heparan Sulfate Oligosaccharides Using Graphitized Carbon Liquid Chromatography and Electrospray Mass Spectrometry'. Analytical Chemistry. DOI > view in repository >
- Turnbull, Jeremy; Guimond. 01-01-2017. 'Sulfatase-mediated manipulation of the astrocyte-Schwann cell interface.'. Glia. DOI > view in repository >
- Duckworth, Carrie A.; Guimond, Scott E.; Sindrewicz, Paulina; Hughes, Ashley J.; French, Neil S.; Lian, Lu-Yun; Yates, Edwin A.; Pritchard, D. Mark; Rhodes, Jonathan M.; Turnbull, Jeremy E.; Yu, Lu-Gang. 15-09-2015. 'Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis'. Oncotarget. DOI > view in repository >
- Bromfield, Stephen M.; Posocco, Paola; Chan, Ching W.; Calderon, Marcelo; Guimond, Scott E.; Turnbull, Jeremy E.; Pricl, Sabrina; Smith, David K.. 01-01-2014. 'Nanoscale self-assembled multivalent (SAMul) heparin binders in highly competitive, biologically relevant, aqueous media'. Chemical Science. DOI > view in repository >
- Solari, Valeria; Rudd, Timothy R.; Guimond, Scott E.; Powell, Andrew K.; Turnbull, Jeremy E.; Yates, Edwin A.. . 'Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding'. Organic & Biomolecular Chemistry. DOI > view in repository >
- Rogerson, Evelyn; Pelletier, Julien; Acosta-Serrano, Alvaro; Rose, Clair; Taylor, Sarah; Guimond, Scott; Lima, Marcelo; Skidmore, Mark; Yates, Edwin. 19-03-2018. 'Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans'. Pathogens. DOI > view in repository >
- Skidmore, Mark; Mohd Fadzli Mustaffa, Khairul; Cooper, Lynsay C.; Guimond, Scott E.; Yates, Edwin A.; Craig, Alister G.. 18-10-2017. 'A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence'. PLoS One. DOI > view in repository >
- Ghadiali, R.S.; Guimond, S.E.; Turnbull, J.E.; Pisconti, A.. 01-05-2017. 'Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling'. Matrix Biology. DOI > view in repository >
- Theodoraki, Aikaterini; Hu, Youli; Poopalasundaram, Subathra; Oosterhof, Arie; Guimond, Scott E.; Disterer, Petra; Khoo, Bernard; Hauge-Evans, Astrid C.; Jones, Peter M.; Turnbull, Jeremy E.; van Kuppevelt, Toin H.; Bouloux, Pierre-Marc. 01-01-2015. 'Distinct patterns of heparan sulphate in pancreatic islets suggest novel roles in paracrine islet regulation'. Molecular and Cellular Endocrinology. DOI > view in repository >
- Chan, Wai Kit; Howe, Katherine; Clegg, James M.; Guimond, Scott E.; Price, David J.; Turnbull, Jeremy E.; Pratt, Thomas. . '2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline'. PLOS ONE. DOI > view in repository >
- Tyler, Peter C.; Guimond, Scott E.; Turnbull, Jeremy E.; Zubkova, Olga V.. 23-02-2015. 'Single-Entity Heparan Sulfate Glycomimetic Clusters for Therapeutic Applications'. Angewandte Chemie International Edition. DOI > view in repository >
- Kalus, Ina; Rohn, Susanne; Puvirajesinghe, Tania M.; Guimond, Scott E.; Eyckerman-Kölln, Pieter J.; ten Dam, Gerdy; van Kuppevelt, Toin H.; Turnbull, Jeremy E.; Dierks, Thomas. . 'Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions'. PLOS ONE. DOI > view in repository >
- Skidmore, Mark A.; Kajaste-Rudnitski, Anna; Wells, Nicola M.; Guimond, Scott E.; Rudd, Timothy R.; Yates, Edwin A.; Vicenzi, Elisa. . 'Inhibition of influenza H5N1 invasion by modified heparin derivatives'. MedChemComm. DOI > view in repository >
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Other
- Mycroft-West, Courtney J.; Su, Dunhao; Pagani, Isabel; Rudd, Timothy R.; Elli, Stefano; Guimond, Scott E.; Miller, Gavin; Meneghetti, Maria C. Z.; Nader, Helena B.; Li, Yong; Nunes, Quentin M.; Procter, Patricia; Mancini, Nicasio; Clementi, Massimo; Bisio, Antonella; Forsyth, Nicholas R.; Turnbull, Jeremy E.; Guerrini, Marco; Fernig, David G.; Vicenzi, Elisa; Yates, Edwin A.; Lima, Marcelo A.; Skidmore, Mark A.. . 'Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin'. . DOI > view in repository >
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School of Medicine
David Weatherall building
University Road
Keele University
Staffordshire
ST5 5BG
Tel: +44 (0) 1782 733937
Email: fmhs.facilities@keele.ac.uk
Admissions enquiries: enquiries@keele.ac.uk
The Clinical Education Centre
Keele University
Clinical Education Centre
University Hospitals of North Midlands NHS Trust
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Stoke-on-Trent
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ST4 6QG
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