Research lecture in Dublin
Dr Matt O'Brien, Lecturer in Organic Chemistry, presented a research lecture at University College Dublin, entitled 'Diastereoselection on conformationally well-defined scaffolds'.Focusing on one of Matt's main research interests, the lecture explained how the use of epimerisable furanyl-ether chiral centres can provide very high levels of stereocontrol when used in the synthesis of tetrahydropyrans, piperidines and spiroketals.
The lecture also explained how these scaffolds can be used as temporary stereochemical relays for remote asymmetric induction (e.g. in the synthesis of 1,9 anti-diols).