Professor Gavin J. Miller
- Title
- Professor of Biological Chemistry
- Location
- Lennard-Jones: 1.08
- Role
- MRes Programme Director
- Contact me
- E-mail me for an appointment
- Phone
- +44 01782 734442
- g.j.miller@keele.ac.uk
Biography
Biography
Gavin Miller was born in Newport, Wales and read Chemistry with Medicinal Chemistry at UMIST where he was awarded an MChem. Continuing his studies at the University of Manchester, Gavin undertook a PhD in carbohydrate chemistry (investigating multivalency).
He then undertook PDRA positions at Brown University (polyketides) and St Andrews University (inositol mimetics). Gavin then worked in industry, firstly at Ferring Pharmaceuticals, on the design of new treatments for primary dysmenorrhea and secondly at Peakdale Molecular on the design of an anti-nicotine vaccine.
Gavin returned to academia and the University of Manchester in 2009, firstly as a PDRA in the Manchester Institute of Biotechnology developing chemical synthesis approaches to heparan sulfate oligosaccharides and secondly as a fixed-term lecturer, in 2014, within the School of Chemistry.
He took up his current lectureship in chemistry at Keele in 2016 and was promoted to Professor of Biological Chemistry in 2021.
Research and scholarship
Research and scholarship
Our research program in glycoscience sits at the chemistry/biology interface. We are developing synthetic and chemoenzymatic methodologies to construct important biological carbohydrates. Some examples are illustrated below. For more information please visit the Group research pages and follow us on Twitter.
Teaching
Teaching
- CHE-40052: MRes Research Project
- CHE-40024: Research Topics in Chemistry
- CHE-40021: MChem Research Project
- CHE-30039: Advanced Organic Chemistry
Publications
Publications
Journal Articles
- Dolan, Jonathan P; Keenan, Tessa; Cheallaigh, Aisling Ni; Fascione, Martin A.; Miller, Gavin J. 25-03-2025. '3′-O-β-Glucosylation of nucleoside analogues using a promiscuous bacterial glycosyltransferase'. RSC Chemical Biology. DOI > view in repository >
- Evans, Sean T.; Tizzard, Graham J.; Field, Robert A.; Miller, Gavin J.. 01-11-2024. 'Towards the synthesis of a 2-deoxy-2-fluoro-d-mannose building block and characterisation of an unusual 2-S-phenyl anomeric pyridinium triflate salt via 1 → 2 S-migration'. Carbohydrate Research. DOI > view in repository >
- Leslie, Kathryn G.; Berry, Sian S.; Miller, Gavin J.; Mahon, Clare S.. 09-10-2024. 'Sugar-Coated: Can Multivalent Glycoconjugates Improve upon Nature’s Design?'. Journal of the American Chemical Society. DOI > view in repository >
- Porter, Jack; Roberts, Jacob; Miller, Gavin J. . 'Benzoylation of Tetrols: A Comparison of Regioselectivity Patterns for O- and S-Glycosides of d-Galactose'. The Journal of Organic Chemistry. DOI > view in repository >
- Wootton, Hannah S.; Berry, Sian S.; Ferguson, Elaine L.; Mahon, Clare S.; Miller, Gavin J. . 'Adaptable Synthesis of Chondroitin Sulfate Disaccharide Subtypes Preprogrammed for Regiospecific O‐Sulfation'. European Journal of Organic Chemistry. DOI > view in repository >
- Wahart, Alice J. C.; Beardmore, Liam N. D.; Field, Robert A.; Cosgrove, Sebastian C.; Miller, Gavin J.. . 'Tandem One-Pot Biocatalytic Oxidation and Wittig Reaction in Water'. Organic Letters. DOI > view in repository >
- Wootton, Hannah S.; J. Miller, Gavin. 01-07-2024. 'Methyl and Benzyl (Ethyl 3,4-di-O-benzyl-2-O-benzoyl-1-thio-β-d-glucopyranosyl)uronate'. Molbank. DOI > view in repository >
- Porter, Jack; Noble, Amanda R.; Signoret, Nathalie; Fascione, Martin A.; Miller, Gavin J.. . 'Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug'. ACS Omega. DOI > view in repository >
- Dolan, Jonathan P.; Ahmadipour, Sanaz; Wahart, Alice J. C.; Cheallaigh, Aisling Ní; Sari, Suat; Eurtivong, Chatchakorn; Lima, Marcelo A.; Skidmore, Mark A.; Volcho, Konstantin P.; Reynisson, Jóhannes; Field, Robert A.; Miller, Gavin J.. . 'Correction: Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors'. RSC Chemical Biology. DOI > view in repository >
- Westarp, Sarah; Benckendorff, Caecilie; Motter, Jonas; Rohrs, Viola; Sanghvi, Yogesh; Neubauer, Peter; Kurreck, Jens; Kurreck, Anke; Miller, Gavin J. . 'Biocatalytic Nucleobase Diversification of 4'‐Thionucleosides and Application of Derived 5‐Ethynyl‐4'‐thiouridine for RNA synthesis detection'. Angewandte Chemie. DOI > view in repository >
- Westarp, Sarah; Benckendorff, Caecilie; Motter, Jonas; Rohrs, Viola; Sanghvi, Yogesh; Neubauer, Peter; Kurreck, Jens; Kurreck, Anke; Miller, Gavin J. . 'Biocatalytic Nucleobase Diversification of 4'-Thionucleosides and Application of Derived 5-Ethynyl-4'-thiouridine for RNA synthesis detection.'. Angewandte Chemie (International ed. in English). DOI > view in repository >
- Pongener, Imlirenla; Sletten, Eric T.; Danglad-Flores, José; Seeberger, Peter H.; Miller, Gavin J.. . 'Synthesis of a heparan sulfate tetrasaccharide using automated glycan assembly †'. Organic & Biomolecular Chemistry. DOI > view in repository >
- Hoolachan, Joseph M; McCallion, Eve; Sutton, Emma R; Çetin, Özge; Pacheco-Torres, Paloma; Dimitriadi, Maria; Sari, Suat; Miller, Gavin J; Okoh, Magnus; Walter, Lisa M; Claus, Peter; Wood, Matthew JA; Tonge, Daniel; Bowerman, Melissa. 01-03-2024. 'A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models.'. Human molecular genetics. DOI > view in repository >
- Porter, Jack; Parisi, Daniele; Miller, Timothy; Cheallaigh, Aisling Ní; Miller, Gavin J. 01-08-2023. 'Chemical synthesis of amphiphilic glycoconjugates: Access to amino, fluorinated and sulfhydryl oleyl glucosides.'. Carbohydrate research. DOI > view in repository >
- Miller, Gavin J.. 01-07-2023. 'Early career researchers in glycoscience'. Carbohydrate Research. DOI > view in repository >
- Motter, Jonas; Benckendorff, Caecilie M. M.; Westarp, Sarah; Sunde-Brown, Peter; Neubauer, Peter; Kurreck, Anke; Miller, Gavin J.. . 'Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology'. Natural Product Reports. DOI > view in repository >
- Wahart, Alice J. C.; Dolan, Jonathan P.; Anderson, Simon D.; Cheallaigh, Aisling Ní; Staniland, Jessica; Lima, Marcelo A.; Skidmore, Mark A.; Miller, Gavin J.; Cosgrove, Sebastian C.. 09-11-2023. 'Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides'. ChemBioChem. DOI > view in repository >
- Wahart, Alice J C; Dolan, Jonathan P; Anderson, Simon D; Cheallaigh, Aisling Ní; Staniland, Jessica; Lima, Marcelo A; Skidmore, Mark A; Miller, Gavin J; Cosgrove, Sebastian C. . 'Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides.'. Chembiochem : a European journal of chemical biology. DOI > view in repository >
- Benckendorff, Caecilie M. M.; Sanghvi, Yogesh S.; Miller, Gavin J.. 01-09-2023. 'Preparation of a 4′‐Thiouridine Building‐Block for Solid‐Phase Oligonucleotide Synthesis'. Current Protocols. DOI > view in repository >
- Dolan, Jonathan; Ahmadipour, Sanaz; Wahart, Alice; Ni Cheallaigh, Aisling; Sari, Suat; Eurtivong,, Chatchakorn; Lima, Marcelo; Skidmore, Mark; Volcho, Konstantin; Reynisson, Jóhannes; Field, Robert; Miller, Gavin. 29-08-2023. 'Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors †'. RSC Chemical Biology. DOI > view in repository >
- Cosgrove; Miller; Dolan, Jonathan. 07-12-2022. 'Biocatalytic Approaches to Building Blocks for Enzymatic and Chemical Glycan Synthesis'. JACS Au. DOI > view in repository >
- Meneghetti, MCZ; Naughton, L; O'Shea, C; Koffi Teki, DS-E; Chagnault, V; Nader, HB; Rudd, TR; Yates, EA; Kovensky, J; Miller, Gavin; Andrade De Lima, Marcelo. 19-07-2022. 'Using NMR to Dissect the Chemical Space and O-Sulfation Effects within the O- and S-Glycoside Analogues of Heparan Sulfate.'. ACS Omega. DOI > view in repository >
- Ahmadipour, Sanaz; Reynisson, Jóhannes; Field, Robert A; Miller, Gavin J. 01-03-2022. 'Sweet targets: sugar nucleotide biosynthesis inhibitors.'. Future Medicinal Chemistry. DOI > view in repository >
- Cosgrove, Sebastian C.; Miller, Gavin J.. 08-02-2022. 'Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues.'. Expert Opinion on Drug Discovery. DOI > view in repository >
- Beswick, Laura; Dimitriou, Eleni; Ahmadipour, Sanaz; Zafar, Ayesha; Rejzek, Martin; Reynisson, Johannes; Field, Robert; Miller, Gavin. 18-12-2020. 'Inhibition of the GDP-d-Mannose Dehydrogenase from Pseudomonas aeruginosa Using Targeted Sugar Nucleotide Probes'. ACS Chemical Biology. DOI > view in repository >
- Mycroft-West, Courtney; Su, Dunhao; Elli, Stefano; Li, Yong; Guimond, Scott; Miller, Gavin; Turnbull, Jeremy; Yates, Edwin; Guerrini, Marco; Fernig, David; Lima, Marcelo; Skidmore, Mark. 01-01-2020. 'The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding'. . DOI > view in repository >
- Avizienyte, Egle; Cole, Claire L.; Rushton, Graham; Miller, Gavin J.; Bugatti, Antonella; Presta, Marco; Gardiner, John M.; Jayson, Gordon C.. 04-08-2016. 'Synthetic Site-Selectively Mono-6-<i>O</i>-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties <i>In Vitro</i> and Sensitizes Tumors to Cisplatin <i>In Vivo</i>'. PLOS ONE. DOI > view in repository >
- Keenan, Tessa; Hatton, Natasha E.; Porter, Jack; Vendeville, Jean-Baptiste; Wheatley, David E.; Ghirardello, Mattia; Wahart, Alice. J. C.; Ahmadipour, Sanaz; Walton, Julia; Galan, M. Carmen; Linclau, Bruno; Miller, Gavin J.; Fascione, Martin A.. . 'Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1,4GlcNAc library †'. Chemical Science. DOI > view in repository >
- Pongener, Imlirenla; Miller, Gavin J.. . 'd-Glucuronate and d-Glucuronate Glycal Acceptors for the Scalable Synthesis of d-GlcN-α-1,4-d-GlcA Disaccharides and Modular Assembly of Heparan Sulfate'. The Journal of Organic Chemistry. DOI > view in repository >
- P Dolan, Jonathan; MM Benckendorff, Caecilie; A Field, Robert; J Miller, Gavin. 19-07-2023. 'Fluorinated nucleosides, nucleotides and sugar nucleotides'. Future Medicinal Chemistry. DOI > view in repository >
- Wittmann, Christopher; Dömötör, Orsolya; Kuznetcova, Irina; Spengler, Gabriella; Reynisson, Jóhannes; Holder, Lauren; Miller, Gavin J.; Enyedy, Eva A.; Bai, Ruoli; Hamel, Ernest; Arion, Vladimir B.. 04-07-2023. 'Indolo[2,3- e ]benzazocines and indolo[2,3- f ]benzazonines and their copper( ii ) complexes as microtubule destabilizing agents †'. Dalton Transactions. DOI > view in repository >
- Benckendorff, Caecilie M. M.; Hawes, Chris S.; Smith, Mark; Miller, Gavin J.. 31-05-2023. 'Chemical Diversification of Carbocyclic Fluorinated Pyrimidine Nucleosides: Introducing 2'-Arabino Analogues and Ring Unsaturation'. SYNLETT. DOI > view in repository >
- Mycroft-West, Courtney J.; Su, Dunhao; Li, Yong; Guimond, Scott E.; Rudd, Timothy R.; Elli, Stefano; Miller, Gavin; Nunes, Quentin M.; Procter, Patricia; Bisio, Antonella; Forsyth, Nicholas R.; Turnbull, Jeremy E.; Guerrini, Marco; Fernig, David G.; Yates, Edwin A.; Lima, Marcelo A.; Skidmore, Mark A.. . 'SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins'. arXiv. DOI > view in repository >
- Mycroft-West, Courtney J.; Su, Dunhao; Li, Yong; Guimond, Scott E.; Rudd, Timothy R.; Elli, Stefano; Miller, Gavin; Nunes, Quentin M.; Procter, Patricia; Bisio, Antonella; Forsyth, Nicholas R.; Turnbull, Jeremy E.; Guerrini, Marco; Fernig, David G.; Yates, Edwin A.; Lima, Marcelo A.; Skidmore, Mark A.. . 'Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain'. bioRxiv. DOI > view in repository >
- Porter, Jack; Miller, Gavin J.. 01-03-2025. '3,4,6-Tri-O-acetyl-1-S-acetyl-2-deoxy-2-S-phenylthio-α-d-mannopyranoside'. Molbank. DOI > view in repository >
- O’Shea, Conor; Miller, Gavin J.. 01-12-2024. 'Synthesis of S-Glycoside Building Blocks as Mimetics of the Repeating d-GlcN-α-1,4-d-GlcA Heparan Sulfate Disaccharide'. Molecules. DOI > view in repository >
- Benckendorff, Caecilie M. M.; Sunde-Brown, Peter; Ní Cheallaigh, Aisling; Miller, Gavin J. 21-11-2024. 'Synthesis of Nucleoside Analogs Containing Sulfur or Selenium Replacements of the Ribose Ring Oxygen or Carbon.'. The Journal of Organic Chemistry (JOC). DOI > view in repository >
- Cosgrove, Sebastian C.; Miller, Gavin J.; Bornadel, Amin; Dominguez, Beatriz. 01-06-2023. 'Realizing the Continuous Chemoenzymatic Synthesis of Anilines Using an Immobilized Nitroreductase'. ACS Sustainable Chemistry & Engineering. DOI > view in repository >
- Mycroft-West, CJ; Devlin, AJ; Cooper, LC; Guimond, S; Procter, P; Miller, G; Guerrini, M; Fernig, DG; Yates, EA; Andrade De Lima, M; Skidmore, M. 01-03-2023. 'A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease ß-site amyloid precursor protein cleaving enzyme 1 (BACE-1).'. Carbohydrate Research. DOI > view in repository >
- Porter, Jack; Lima, Marcelo A.; Pongener, Imlirenla; Miller, Gavin. 01-02-2023. 'Synthesis of 4-thio-d-glucopyranose and interconversion to 4-thio-d-glucofuranose.'. Carbohydrate Research. DOI > view in repository >
- Benckendorff, Caecilie; Slyusarchuk, Valentyna D.; Huang, Ningwu; Lima, Marcelo A.; Smith, Mark; Miller, Gavin J.. 07-12-2022. 'Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues'. Organic & Biomolecular Chemistry. DOI > view in repository >
- Ahmadipour, Sanaz; Wahart, AJC; Dolan, JP; Beswick, Laura; Hawes, CS; Field, RA; Miller, GJ. 30-09-2022. 'Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase.'. Beilstein Journal of Organic Chemistry. DOI > view in repository >
- Guinan, Mieke; Huang, Ningwu; Smith, Mark; Miller, Gavin. 01-04-2022. 'Design, chemical synthesis and antiviral evaluation of 2'-deoxy-2'-fluoro-2'-C-methyl-4'-thionucleosides.'. Bioorganic & Medicinal Chemistry Letters. DOI > view in repository >
- Wahart, Alice J. C.; Staniland, Jessica; Miller, Gavin J.; Cosgrove, Sebastian C.. 01-01-2022. 'Oxidase enzymes as sustainable oxidation catalysts'. Royal Society Open Science. DOI > view in repository >
- Ahmadipour, Sanaz; Field, Robert A.; Miller, Gavin. 01-12-2021. 'Prospects for anti-Candida therapy through targeting the cell wall: A mini-review'. The Cell Surface. DOI > view in repository >
- Guinan, Mieke; Huang, Ningwu; Hawes, Chris S.; Lima, Marcelo A.; Smith, Mark; Miller, Gavin J.. 22-11-2021. 'Chemical synthesis of 4′-thio and 4′-sulfinyl pyrimidine nucleoside analogues'. Organic & Biomolecular Chemistry. DOI > view in repository >
- Pongener, Imlirenla; O'Shea, Conor; Wootton, Hannah; Watkinson, Michael; Miller, Gavin J.. 01-11-2021. 'Developments in the Chemical Synthesis of Heparin and Heparan Sulfate'. The Chemical Record. DOI > view in repository >
- Dimitriou, Eleni; Miller, Gavin. 05-07-2021. 'Chemical synthesis of C6-tetrazole ᴅ-mannose building blocks and access to a bioisostere of mannuronic acid 1-phosphate'. Beilstein Journal of Organic Chemistry. DOI > view in repository >
- Mycroft-West, Courtney J.; Devlin, Anthony J.; Cooper, Lynsay C.; Guimond, Scott E.; Procter, Patricia; Guerrini, Marco; Miller, Gavin J.; Fernig, David G.; Yates, Edwin A.; Lima, Marcelo A.; Skidmore, Mark A.. 03-04-2021. 'Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer’s Disease ß Secretase, BACE1'. Marine Drugs. DOI > view in repository >
- Mycroft-West, Courtney J.; Su, Dunhao; Pagani , Isabel; Rudd , Timothy R.; Elli , Stefano; Gandhi , Neha S.; Guimond , Scott E.; Miller, Gavin J.; Meneghetti, Maria C.Z.; Nader, Helena B.; Li, Yong; Nunes, Quentin M.; Procter, Patricia; Mancini, Nicasio; Clementi, Massimo; Bisio, Antonella; Forsyth, Nicholas R.; Ferro, Vito; Turnbull , Jeremy E.; Guerrini , Marco; Fernig , David G.; Vicenzi , Elisa; Yates , Edwin A.; Lima , Marcelo A.; Skidmore , Mark A.. 23-12-2020. 'Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin.'. Thrombosis and Haemostasis. DOI > view in repository >
- Beswick, Laura; Dimitriou, Eleni; Ahmadipour, Sanaz; Zafar, Ayesha; Rejzek, Martin; Reynisson, Jóhannes; Field, Robert A.; Miller, Gavin J.. 18-12-2020. 'Inhibition of the GDP-d-Mannose Dehydrogenase from Pseudomonas aeruginosa Using Targeted Sugar Nucleotide Probes'. ACS Chemical Biology. DOI > view in repository >
- Singh, Meenakshi; Watkinson, Mike; Scanlan, Eoin M.; Miller, Gavin. 17-09-2020. 'Illuminating glycoscience: synthetic strategies for FRET-enabled carbohydrate active enzyme probes'. RSC Chemical Biology. view in repository >
- Ní Cheallaigh, Aisling; Guimond, Scott; Oscarson, Stefan; Miller, Gavin. 01-09-2020. 'Chemical synthesis of a sulfated d-glucosamine library and evaluation of cell proliferation capabilities.'. Carbohydrate Research. DOI > view in repository >
- Miller, Gavin J.. 07-08-2020. 'Unifying the synthesis of nucleoside analogs'. Science. DOI > view in repository >
- Guinan, Mieke; Benckendorff, Caecilie; Smith, Mark; Miller, Gavin. 28-04-2020. 'Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues.'. Molecules. DOI > view in repository >
- Beswick, Laura; Ahmadipour, Sanaz; Hofman, Gert-Jan; Wootton, Hannah; Dimitriou, Eleni; Reynisson, Jóhannes; Field, Robert A.; Linclau, Bruno; Miller, Gavin J.. 01-02-2020. 'Exploring anomeric glycosylation of phosphoric acid: Optimisation and scope for non-native substrates.'. Carbohydrate Research. DOI > view in repository >
- Mycroft-West, Courtney J.; Devlin, Anthony J.; Cooper, Lynsay C.; Procter, Patricia; Miller, Gavin J.; Fernig, David G.; Guerrini, Marco; Guimond, Scott E.; Lima, Marcelo A.; Yates, Edwin A.; Skidmore, Mark Andrew. 28-01-2020. 'Inhibition of BACE1, the ß-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus.'. Neural Regeneration Research. DOI > view in repository >
- Dimitriou, Eleni; Miller, Gavin. 18-01-2020. 'Synthesis and Isolation of Diastereomeric Anomeric Sulfoxides from a d-Mannuronate Thioglycoside Building Block'. Molbank. DOI > view in repository >
- Beswick, Laura; Ahmadipour, Sanaz; Dolan, Jonathan P.; Rejzek, Martin; Field, Robert A.; Miller, Gavin J.. 01-11-2019. 'Chemical and enzymatic synthesis of the alginate sugar nucleotide building block: GDP-d-mannuronic acid'. Carbohydrate Research. DOI > view in repository >
- Dimitriou, Eleni; Miller, Gavin. 04-10-2019. 'Exploring a glycosylation methodology for the synthesis of hydroxamate-modified alginate building blocks'. Organic & Biomolecular Chemistry. DOI > view in repository >
- Miller, Gavin; Ahmadipour, Sanaz. 27-06-2019. '6R/S-deutero-a-d-mannopyranoside 1-phosphate'. Molbank. DOI > view in repository >
- Ahmadipour, Sanaz; Pergolizzi, Giulia; Rejzek, Martin; Field, Robert A.; Miller, Gavin J.. 21-06-2019. 'Chemoenzymatic Synthesis of C6-Modified Sugar Nucleotides To Probe the GDP-d-Mannose Dehydrogenase from Pseudomonas aeruginosa'. Organic Letters. DOI > view in repository >
- Dimitriou, E; Jones, R; Pritchard, R; Miller, G; O'Brien, M. 22-11-2018. 'Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1,4]diazepine scaffold'. Tetrahedron. DOI > view in repository >
- Ahmadipour, Sanaz; Beswick, Laura; Miller, Gavin. 01-11-2018. 'Recent advances in the enzymatic synthesis of sugar-nucleotides using nucleotidylyltransferases and glycosyltransferases'. Carbohydrate Research. DOI > view in repository >
- Potter, Garrett T.; Jayson, Gordon C.; Gardiner, John M.; Guazelli, Lorenzo; Miller, Gavin. 24-03-2018. 'Chapter 18: Synthesis of 1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-α,β-d- glucopyranose Using the Diazo-Transfer Reagent Imidazole-1- sulfonyl Azide Hydrogen Sulfate By Garrett T. Potter, Gordon C. Jayson, John M. Gardiner, Lorenzo Guazelli, and Gavin J. Miller'. Journal of Carbohydrate Chemistry. DOI > view in repository >
- Ahmadipour, Sanaz; Miller, Gavin. 08-11-2017. 'Recent advances in the chemical synthesis of sugar-nucleotides'. Carbohydrate Research. DOI > view in repository >
- Miller, Gavin; Beswick, Laura. 14-07-2017. '1,2,3,4-Tetra-O-Acetyl- ß-D-Mannuronic Acid'. Molbank. DOI > view in repository >
- Miller. 04-08-2016. 'Synthetic Site-Selectively Mono-6-O-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties In Vitro and Sensitizes Tumors to Cisplatin In Vivo'. PLoS One. DOI > view in repository >
- Ní Cheallaigh, Aisling; Potter, Garrett T.; Gardiner, John M.; Miller, Gavin. 07-06-2016. 'Preparation of Methyl 1,2,3,4-tetra-O-acetyl-B-D-glucopyranuronate'. Organis Syntheses. DOI > view in repository >
- Potter, Garrett T.; Jayson, Gordon C.; Miller, Gavin J.; Gardiner, John M.. 15-04-2016. 'An Updated Synthesis of the Diazo-Transfer Reagent Imidazole-1-sulfonyl Azide Hydrogen Sulfate'. The Journal of Organic Chemistry. DOI > view in repository >
- Miller; Miller, Gavin J.; Broberg, Karl. R.; Rudd, Claire; Helliwell, Madeleine R.; Jayson, Gordon C.; Gardiner, John M.. 09-09-2015. 'A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides'. Organic & Biomolecular Chemistry. DOI > view in repository >
- Potter, Garrett T.; Jayson, Gordon C.; Miller, Gavin J.; Gardiner, John M.. 09-09-2015. 'Amyl nitrite-mediated conversion of aromatic and heteroaromatic primary amides to carboxylic acids'. Tetrahedron Letters. DOI > view in repository >
- Hansen, Steen U.; Miller, Gavin J.; Cliff, Matthew J.; Jayson, Gordon C.; Gardiner, John M.. 24-07-2015. 'Making the longest sugars: a chemical synthesis of heparin-related [4](n) oligosaccharides from 16-mer to 40-mer'. Chemical Science. DOI > view in repository >
- Jayson, Gordon C.; Hansen, Steen U.; Miller, Gavin J.; Cole, Claire L.; Rushton, Graham; Avizienytea, Egle; Gardiner, John M.. 22-07-2015. 'Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology'. Chemical Communications. DOI > view in repository >
- Baráth, Marek; Hansen, Steen U.; Dalton, Charlotte E.; Jayson, Gordon C.; Miller, Gavin J.; Gardiner, John M.. 09-04-2015. 'Modular Synthesis of Heparin-Related Tetra-, Hexa- and Octasaccharides with Differential O-6 Protections: Programming for Regiodefined 6-O-Modifications'. Molecules. DOI > view in repository >
- Hansen, Steen U.; Dalton, Charlotte E.; Baráth, Marek; Kwan, Glenn; Raftery, James; Jayson, Gordon C.; Miller, Gavin J.; Gardiner, John M.. 03-02-2015. 'Synthesis of L-Iduronic Acid Derivatives via [3.2.1] and [2.2.2] L-Iduronic Lactones from Bulk Glucose-Derived Cyanohydrin Hydrolysis: A Reversible Conformationally Switched Superdisarmed/Rearmed Lactone Route to Heparin Disaccharides'. Journal Of Organic Chemistry. DOI > view in repository >
- Miller, Gavin J.; Hansen, Steen U.; Baráth, Marek; Johannessen, Christian; Blanch, Ewan W.; Jayson, Gordon C.; Gardiner, John M.. 05-12-2014. 'Synthesis of a heparin-related GlcN-IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy'. Carbohydrate Research. DOI > view in repository >
- Jayson, Gordon C.; Miller, Gavin J.; Hansen, Steen U.; Barath, Marek; Gardiner, John M.; Avizienyte, Egle. 01-12-2014. 'The development of anti-angiogenic heparan sulfate oligosaccharides'. Biochemical Society Transactions. DOI > view in repository >
- Pryde, David C.; Jones, Lyn H.; Gervais, David P.; Stead, David R.; Blakemore, David C.; Selby, Matthew D.; Brown, Alan D.; Coe, Jotham W.; Badland, Matthew; Beal, David M.; Glen, Rebecca; Wharton, Yvonne; Miller, Gavin J.; White, Phil; Zhang, Ningli; Benoit, Michelle; Robertson, Karen; Merson, James R.; Davis, Heather L.; McCluskie, Michael J.. 01-10-2013. 'Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice'. PLoS One. DOI > view in repository >
- Takemoto, Naohiro; Suehara, Tetsuya; Frisco, Heidie L.; Sato, Shin-ichi; Sezaki, Takuhito; Kusamori, Kosuke; Kawazoe, Yoshinori; Min Park, Sun; Yamazoe, Sayumi; Mizuhata, Yoshiyuki; Inoue, Rintaro; Miller, Gavin J.; Hansen, Steen U.; Jayson∥, Gordon C.; Gardiner, John M.; Kanaya, Toshiji; Tokitoh, Norihiro; Ueda, Kazumitsu; Takakura, Yoshinobu; Kioka, Noriyuki; Nishikawa, Makiya; Uesugi, Motonari. 31-07-2013. 'Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion'. Journal Of The American Chemical Society. DOI > view in repository >
- Hansen, Steen U.; Miller, Gavin J.; Cole, Claire; Rushton, Graham; Avizienyte, Egle; Jayson, Gordon C.; Gardiner, John M.. 05-07-2013. 'Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies'. Nature Communications. DOI > view in repository >
- Miller, Gavin J.; Hansen, Steen U.; Avizienyte, Egle; Rushton, Graham; Cole, Claire; Jayson, Gordon C.; Gardiner, John M.. 28-05-2013. 'Efficient chemical synthesis of heparin-like octa-, deca- and dodecasaccharides and inhibition of FGF2-and VEGF(165)-mediated endothelial cell functions'. Chemical Science. DOI > view in repository >
- Hansen, Steen U.; Miller, Gavin J.; Jayson, Gordon C.; Gardiner, John M.. 04-01-2013. 'First Gram-Scale Synthesis of a Heparin-Related Dodecasaccharide'. Organic Letters. DOI > view in repository >
- Miller. 17-08-2012. 'Synthesis and Scalable Conversion of l-Iduronamides to Heparin-Related Di- and Tetrasaccharides'. Journal Of Organic Chemistry. DOI > view in repository >
- Miller. 18-04-2011. 'A synthesis of C-glycosidic multivalent mannosides suitable for divergent functionalized conjugation'. Tetrahedron Letters. DOI > view in repository >
- Miller. 19-11-2010. 'Adaptable Synthesis of C-Glycosidic Multivalent Carbohydrates and Succinamide-Linked Derivatization'. Organic Letters. DOI > view in repository >
- Miller. 01-12-2009. 'Thieme Chemistry Journal Awardees - Where are They Now? Synthesis of the Marine Glycolipid Dioctadecanoyl Discoside'. Synlett. DOI > view in repository >
- Miller. 17-03-2007. 'Biology-enabling inositol phosphates, phosphatidylinositol phosphates and derivatives'. Natural Product Reports. DOI > view in repository >
- Sunde-Brown, Peter; Miller, Gavin J.; Houston, Todd A.. . 'Multigram-Scale Synthesis of 2,5-Dideoxy-2,5-imino-d-mannitol (DMDP) and 2,5-Dideoxy-2,5-imino-d-glucitol (DGDP) from d-Fructose and l-Sorbose Using a Regioselective Appel Reaction.'. The Journal of organic chemistry. DOI > view in repository >
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Book Chapter
- Singh, Meenakshi; Watkinson, Michael; Scanlan, Eoin M.; Miller, Gavin J.. 07-10-2021. 'Synthetic Strategies for FRET-Enabled Carbohydrate Active Enzyme Probes'. . DOI > view in repository >
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Other
- Mycroft-West, Courtney J.; Su, Dunhao; Pagani, Isabel; Rudd, Timothy R.; Elli, Stefano; Guimond, Scott E.; Miller, Gavin; Meneghetti, Maria C. Z.; Nader, Helena B.; Li, Yong; Nunes, Quentin M.; Procter, Patricia; Mancini, Nicasio; Clementi, Massimo; Bisio, Antonella; Forsyth, Nicholas R.; Turnbull, Jeremy E.; Guerrini, Marco; Fernig, David G.; Vicenzi, Elisa; Yates, Edwin A.; Lima, Marcelo A.; Skidmore, Mark A.. . 'Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin'. . DOI > view in repository >
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Preprint / Working Paper
- Dolan, Jonathan; Keenan, Tessa; Benckendorff, Caecilie; Ní Cheallaigh, Aisling; Fascione, Martin; Miller, Gavin. . '3’-O-β-Glycosylation of nucleoside analogues using a promiscuous bacterial glycosyltransferase'. . view in repository >
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Presentation / Conference Contribution
- Miller, Gavin; Ahmadipour, Sanaz; Beswick, Laura. 18-03-2018. 'Mimetic sugar-nucleotides to probe a strategic bacterial dehydrogenase enzyme'. . view in repository >
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School address
Lennard-Jones School of Chemical and Physical Sciences
Lennard-Jones Building
Keele University
Staffordshire
ST5 5BG, UK
Phone (School Office): +44 (0)1782 733033, (Chemistry): +44 (0)1782 731693, (Forensic Science): +44 (0)1782 731694, (Physics): +44 (0)1782 733527
Email: scps@keele.ac.uk
Information for schools and colleges
Programme directors
Chemistry and Medicinal Chemistry
Dr Tess Phillips
Tel : +44 (0)1782 733038
Email : t.r.phillips@keele.ac.uk
Dr Chris Hawes
Tel : +44 (0)1782 732820
Email : c.s.hawes@keele.ac.uk
Forensic Science and Criminology
Dr Jamie K. Pringle
Tel : +44 (0)1782 733163
Email : j.k.pringle@keele.ac.uk
Victoria Cartwright
Tel: +44 (0)1782733584
Email: v.cartwright@keele.ac.uk
Physics and Astrophysics
Dr Barry Smalley and Dr Joana Oliveira
Email : b.smalley@keele.ac.uk, j.oliveira@keele.ac.uk
Admission tutors
Chemistry and Medicinal Chemistry
Dr Natalie Capel
Tel : +44 (0)1782 733584
Email : n.j.capel@keele.ac.uk
Forensic Science
Sue Shemilt
Email: s.shemilt@keele.ac.uk
Physics and Astrophysics
Dr Juliana Morbec
Email : physics@keele.ac.uk or j.morbec@keele.ac.uk